PMID: 7540557Apr 1, 1995Paper

Hematologic effects of stem cell factor (SCF) and leukemia inhibitory factor (LIF) in vivo: LIF-induced thrombocytosis in SCF-primed mice

European Journal of Haematology
T R UlichB Samal

Abstract

Stem cell factor (SCF) administered as daily bolus injections in dose-response experiments in mice causes a progressive and dramatic dose-dependent panleukocytosis characterized by neutrophilia, eosinophilia, monocytosis, and lymphocytosis. SCF causes circulating platelet numbers to be dose-dependently increased after 2 weeks of daily injections. Leukemia inhibitory factor (LIF) administered as daily bolus injections in mice causes a peripheral leukopenia that is largely due to peripheral lymphopenia. LIF causes thrombocytosis peaking after approximately 1 w. Coinjection of SCF and LIF for 1 to 2 wk in mice does not cause a much greater thrombocytosis than the maximum thrombocytosis achievable with SCF or LIF alone. On the other hand, daily injection of SCF for 5 days followed by daily injection of LIF for 5 to 6 d in mice causes a very substantial increase in platelets that was lineage-specific in terms of not being accompanied by a generalized leukocytosis. In contrast, only a very modest thrombocytosis was noted in SCF-primed LIF-treated rats. LIF causes a large increase in the cytoplasmic volume of splenic megakaryocytes in mice, but not in rats. In conclusion, SCF-induced priming followed by LIF-induced maturation of megak...Continue Reading

References

Jan 1, 1990·International Journal of Cell Cloning·D Metcalf
Sep 1, 1991·Journal of Cellular Physiology·D J HiltonD Metcalf
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·D J HiltonD Metcalf
Jan 1, 1993·British Journal of Haematology·P WaringD Metcalf

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Citations

Sep 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·G SenaldiM S Chang
Jun 17, 2000·Endocrine Reviews·C J Auernhammer, S Melmed
Apr 8, 1998·British Journal of Haematology·J Guo, P F Piguet
Mar 20, 1998·International Reviews of Immunology·J L TaupinJ F Moreau
Feb 6, 1997·Transfusion Science·T Hamblin

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