Hematologic Malignancies Identified in Patients with Hypereosinophilia and Hypereosinophilic Syndromes

The Journal of Allergy and Clinical Immunology. in Practice
Jay J JinCatherine R Weiler

Abstract

Certain hematologic malignancies are associated with hypereosinophilia or tissue eosinophilia. It is unclear if patients with hypereosinophilia are more likely to develop one of these malignancies. This study sought to quantify the specific hematologic malignancies that developed in patients with preexisting hypereosinophilia. Adult patients with eosinophilia associated with the development of hematologic malignancy were identified by a retrospective review of the Mayo Clinic patient database between 2000 and 2013. Of 2642 patients identified with eosinophilia, hypereosinophilia, or hypereosinophilic syndrome, 25 (aged 28.8 to 86.1 years; 13 male; 12 female) had a diagnosis of either lymphoma or leukemia. The majority of these patients had non-Hodgkin lymphoma (17 of 25). T-cell-derived lymphomas were more common (12 of 17) than B-cell-derived lymphomas (4 of 17). In patients with leukemia (8 of 25), chronic lymphocytic leukemia (4 of 8) was most common, followed by chronic eosinophilic leukemia (3 of 8). Approximately 5.1% of patients with hypereosinophilia developed a hematologic malignancy. On average, the malignancy developed 30.0 ± 42.7 months after the onset of hypereosinophilia. The development of hematologic malignancie...Continue Reading

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Citations

Mar 1, 2018·Expert Opinion on Drug Safety·Mario CazzolaPaola Rogliani
Aug 15, 2018·American Journal of Hematology·Zhihong HuSa A Wang
Apr 25, 2020·Case Reports in Gastrointestinal Medicine·Gregorios ChristodoulidisDimitrios Zacharoulis
May 2, 2018·Tumori·Arash SamarghandiIlmana Fulger
Apr 24, 2018·Current Hematologic Malignancy Reports·Melanie C Dispenza, Bruce S Bochner
May 27, 2017·Military Medical Research·Jean-François MagnavalAntoine Berry
Jan 9, 2020·Current Allergy and Asthma Reports·Joseph CafoneJonathan M Spergel
Jul 25, 2020·Allergy and Asthma Proceedings·Joel P BrooksRyan Steele
Apr 30, 2020·Current Opinion in Allergy and Clinical Immunology
Dec 29, 2020·American Journal of Clinical Pathology·Rebecca L KingLeticia Quintanilla-Martinez
Jul 25, 2019·Journal of Pediatric Hematology/oncology·Işik Odaman AlGönül Aydoğan
Oct 19, 2017·The Journal of Allergy and Clinical Immunology·Jeremy A O'Sullivan, Bruce S Bochner
Jan 7, 2020·Current Opinion in Allergy and Clinical Immunology
Jun 7, 2021·American Journal of Clinical Oncology·Shruti KhuranaYinghong Wang

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