PMID: 9444448Jan 28, 1998Paper

Hematologic response in patients with aplastic anemia after long-term administration of recombinant human granulocyte colony-stimulating factor and erythropoietin

Clinical Therapeutics
S YonekuraT Hotta

Abstract

Twenty patients with aplastic anemia underwent long-term administration (10 weeks) of recombinant human granulocyte colony-stimulating factor (rhG-CSF) in doses from 50 to 800 micrograms/m2 per day by intravenous infusion or 50 to 100 micrograms/m2 per day by subcutaneous injection and re-combinant human erythropoietin (rhEPO) in doses ranging from 2000 to 8000 IU/m2 per day by intravenous injection three times a week for at least 4 weeks. The goal was to evaluate whether therapy ameliorated pancytopenia in these patients as well as to determine its safety. All assessable patients showed a substantial increase in absolute neutrophil count, with a recovery of myeloid components (granulocyte series) in the bone marrow, after 2 to 10 weeks of treatment. An increase > 1.5 g/dL in hemoglobin (Hb) concentration was observed in 2 patients (10%). A decrease > 50% in red cell transfusion requirement was observed in 2 patients (10%). Seven patients showed recovery of neutropenia, anemia, and platelet count. In addition, there was no serious infection before or during therapy, and side effects were mild. Of the 20 patients, 3 showed a dramatic improvement in severe anemia after 10 weeks of treatment accompanying a recovery of erythroid co...Continue Reading

References

Sep 27, 1990·The New England Journal of Medicine·S KojimaT Matsuyama
May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·K IkebuchiM Ogawa
Feb 27, 1986·The New England Journal of Medicine·M A GertzW H Jennings
Jun 5, 1987·Science·S C Clark, R Kamen
Oct 1, 1981·Annals of Internal Medicine·R P GaleJ H Fitchen
Mar 18, 1982·The New England Journal of Medicine·B M CamittaE D Thomas

❮ Previous
Next ❯

Citations

Feb 19, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Yves Beguin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.