Hematological characteristics of patients in coronavirus 19 infection: a systematic review and meta-analysis.

Journal of Community Hospital Internal Medicine Perspectives
Muhammad AsgharTeresa J Lynch

Abstract

Background COVID-19 infection has become a pandemic and a global health issue since its origin in Wuhan, China in December 2019. The present systematic review and meta-analysis aim to assess hematological changes seen in COVID-19 infection and their association with the severity of the disease. Methods Pooled proportions were calculated using both fixed effects model and random effects model. Weighted mean difference and 95% CI were calculated and reported. Results Initial search identified 84 reference articles, 23 relevant articles were selected and reviewed. Compared to general population, the weighted mean difference of WBC count in all COVID-19 patients was lower by 0.97 × 109 mm3 (95% CI = -1.29 to -0.66). In severe COVID-19 patients, the weighted mean difference of platelet count was lower by 23.85 × 109/liter (95% CI = -35.18 to -9.53), as compared to general population. The weighted mean difference of prothrombin time, D-Dimer, and fibrinogen in severe COVID-19 patients was higher by 1.92 seconds (95% CI = 0.01 to 3.84), 6.23 mg/liter (95% CI = 0.11 to 12.36) and 1.88 g/liter (95% CI = 1.18 to 2.48) respectively, as compared to general population. Pooled proportion showed D-Dimer to be elevated in 80.00% (95 % CI = 50....Continue Reading

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Citations

May 8, 2021·Scientific Reports·Amandine Mveang NzogheJoel Fleury Djoba Siawaya
May 16, 2021·Annals of the Academy of Medicine, Singapore·Ashwin Subramaniam, Muhammad Alamgeer
May 16, 2021·Annals of the Academy of Medicine, Singapore·Saikat MitraKollengode Ramanathan
Aug 1, 2021·Advances in Biological Regulation·Sotirios BristogiannisJecko Thachil

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