PMID: 22580533May 15, 2012Paper

Hematological effects of exposure to mixtures of selected ethylene glycol alkyl ethers in rats

Pharmacological Reports : PR
Beata Starek-SwiechowiczAndrzej Starek

Abstract

Exposure to various ethylene glycol monoalkyl ethers (EGAEs) is known to result in hemolytic effect caused by their metabolites, appropriate alkoxyacetic acids, generated via both alcohol dehydrogenase and aldehyde dehydrogenase. It has been shown in many studies that administration of single doses of EGAEs to rats lead to dose- and time-dependent hemolytic anemia. The repeated exposure to isopropoxyethanol (IPE), and butoxyethanol (BE), contrary to methoxyethanol (ME) and ethoxyethanol (EE), resulted in significantly less pronounced hematological changes. While the majority of hematological effects were dramatic at the beginning of the exposure, later these changes clearly regressed despite continued weekly exposure to these ethers. The gradual recovery from the hemolytic anemia may be associated with tolerance development to the hemolytic effect of IPE and BE. ME demonstrated high hematotoxicity, which increased progressively and reached a maximum at the end of 4 week exposure, whereas EE revealed moderate hematological effects. It might be suspected that ME and EE may modified of IPE hemolytic activity in rats simultaneously treated with these compounds. In the rats co-exposed to IPE and ME subcutaneously at a relatively low...Continue Reading

References

May 3, 1979·Biochimica Et Biophysica Acta·T ShigaM Sekiya
Sep 15, 1978·The Biochemical Journal·E C AbrahamC A Lang
Jul 1, 1992·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·P J SabourinR F Henderson
May 1, 1992·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·R J SmialowiczC B Copeland
Mar 1, 1990·Toxicology and Applied Pharmacology·M A MedinskyR F Henderson
Nov 1, 1990·Toxicology and Applied Pharmacology·B I GhanayemH B Matthews
Apr 1, 1988·Scandinavian Journal of Work, Environment & Health·G JohansonB Dynésius
Feb 1, 1986·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·W J Krasavage
Jan 1, 1985·Drug and Chemical Toxicology·K G RömerK J Freundt
Jul 1, 1993·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·R J SmialowiczW C Williams
Jan 1, 1995·Archives of Toxicology·D V Sivarao, H M Mehendale
Jun 22, 1999·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·L AasmoeG Sager
Jul 13, 2000·Human & Experimental Toxicology·B I GhanayemA Nyska
Mar 21, 2001·Archives of Environmental Health·T S ShihT J Smith
Aug 4, 2001·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·B I GhanayemA Nyska
Nov 20, 2004·Archives of Toxicology·David J LockleyFaith M Williams
Feb 12, 2005·Toxicology Letters·P de Ketttenis
Aug 22, 2008·International Journal of Occupational Medicine and Environmental Health·Andrzej StarekWiesław Szymczak
Jan 29, 2011·Pharmacological Reports : PR·Magdalena RegulskaBogusława Budziszewska

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.