Hematological findings in non-treated and gamma-irradiated mice deficient for MIC-1/GDF15

Physiological Research
M HoferK Souček

Abstract

Several members of the TGF-beta family are known to effectively regulate the fate of hematopoietic progenitor cells in a complex and context-dependent manner. Growth differentiation factor-15 (GDF15) is a divergent member of the TGF-beta family. This stress-induced cytokine has been proposed to possess immunomodulatory functions and its high expression is often associated with progression of a variety of pathological conditions. GDF15 is also induced by chemotherapy and irradiation. Very few fundamental studies have been published regarding the effect of GDF15 in hematopoiesis. In this study, we analyzed the hematological status of untreated and gamma-irradiated mice deficient for GDF15 as a result of genetic knock-out (KO), in order to clarify the regulatory role of GDF15 in hematopoiesis. Significant differences between GDF15 KO mice and their pertinent WT controls were found in the parameters of blood monocyte numbers, blood platelet size, and distribution width, as well as in the values of bone marrow granulocyte/macrophage progenitor cells. Different tendencies of some hematological parameters in the GDF15 KO mice in normal conditions and those under exposure of the mice to ionizing radiation were registered. These finding...Continue Reading

References

Oct 5, 1990·Journal of Molecular Biology·S F AltschulD J Lipman
Oct 23, 1997·Proceedings of the National Academy of Sciences of the United States of America·M R BootcovS N Breit
Dec 31, 1997·Biochimica Et Biophysica Acta·R HromasL Lu
Jan 14, 1999·Journal of Leukocyte Biology·W D FairlieS N Breit
Jun 25, 2004·Nucleic Acids Research·Gabriela G Loots, Ivan Ovcharenko
Jun 4, 2005·Nucleic Acids Research·Shannan J Ho SuiWyeth W Wasserman
Jan 30, 2007·Nature Reviews. Immunology·Frank Rosenbauer, Daniel G Tenen
Feb 6, 2007·Biochemical and Biophysical Research Communications·Motonobu OsadaDavid Sidransky
May 15, 2007·Bioinformatics·Sean Davis, Paul S Meltzer
Nov 30, 2007·Nucleic Acids Research·UNKNOWN UniProt Consortium
Dec 13, 2007·Nucleic Acids Research·Dennis A BensonDavid L Wheeler
May 30, 2008·Mutation Research·Igor KoturbashOlga Kovalchuk
Oct 3, 2009·Annals of the New York Academy of Sciences·Sofie Singbrant SöderbergStefan Karlsson
Nov 13, 2009·Nucleic Acids Research·Misha KapusheskyAlvis Brazma
Feb 26, 2010·Current Opinion in Hematology·Toshihiko TannoJeffery L Miller
Jun 26, 2010·Journal of Cellular Physiology·Murielle Mimeault, Surinder K Batra
Oct 5, 2010·Human Reproduction·Karel SoucekAles Hampl
Oct 5, 2010·Annual Review of Medicine·Tomas Ganz, Elizabeta Nemeth
Jan 19, 2011·The Journal of Experimental Medicine·Saskia C A de JagerErik A L Biessen
Oct 11, 2011·Nature Reviews. Immunology·Chao Shi, Eric G Pamer
Dec 3, 2011·Blood Reviews·Sarah L Davis, T J Littlewood
Sep 8, 2012·Nature·UNKNOWN ENCODE Project Consortium
Jan 9, 2013·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·Kengo KatoIkuo Kashiwakura
Oct 29, 2013·Nucleic Acids Research·Constance M SmithMartin Ringwald
Jul 16, 2014·BioMed Research International·Alicja Kasperska-ZającEdyta Machura
Sep 1, 2014·Experimental Cell Research·Michal Malewicz, Thomas Perlmann
Nov 2, 2015·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Nikolett SándorHargita Hegyesi
Dec 22, 2015·Nucleic Acids Research·Andrew YatesPaul Flicek
Aug 29, 2017·Nature Medicine·Shannon E MullicanShamina M Rangwala
Aug 29, 2017·Nature Medicine·Paul J EmmersonXinle Wu
Aug 29, 2017·Nature Medicine·Linda YangSebastian Beck Jørgensen

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Dec 1, 2021·The Journal of Experimental Medicine·Andreas PatsalosLaszlo Nagy

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