Hematological: Low all-cause mortality and low occurrence of antimicrobial resistance in hematological patients with bacteremia receiving no antibacterial prophylaxis: a single-center study

European Journal of Haematology
Christian KjellanderChristian G Giske

Abstract

Bacteremia is a major cause of morbidity and mortality in patients with hematological malignancies. The aim of this study was to define temporal trends in species distribution, antimicrobial susceptibility, and all-cause mortality in bacteremic hospitalized patients receiving no antibacterial prophylaxis during chemotherapy-induced neutropenia. A total of 677 clinical episodes of bacteremia were identified in 463 patients during 2002-2008, and the results were compared with those published from the same institution during 1980-86 and 1988-2001. No major changes in patient selection were introduced during this period. Between 2002 and 2008, the dominating pathogens were Escherichia coli (18%), coagulase-negative staphylococci (15%), viridans streptococci (14%), Klebsiella spp. (10%), and Enterococcus faecium (8%). The 7-d crude mortality rate was 5.2%. Polymicrobial bacteremia was seen in 25.7% of the patients who died within 7 d and in 13.1% of the survivors (P = 0.04). Acquired resistance was rarely observed, but a statistically significant increase in ciprofloxacin resistance in E. coli was observed. Comparing 2002-2008 with historical data from the same institution, the proportion of Gram-positive isolates remained stable at...Continue Reading

References

Jan 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·L A HerwaldtM A Pfaller
Oct 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M CrucianiE Concia
Feb 1, 1997·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J W Hathorn, K Lyke
Aug 1, 1997·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·L S EltingG P Bodey
Jul 24, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·W V Kern
Aug 4, 1998·The Journal of Antimicrobial Chemotherapy·B A Oppenheim
Aug 4, 1998·The Journal of Antimicrobial Chemotherapy·C Viscoli
Nov 9, 2000·Archives of Medical Research·J Gaytán-MartínezJ L Fuentes-Allen
Mar 1, 1996·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Antoine AndremontMonique G. L
Mar 13, 2002·Lancet·Oscar Marchetti, Thierry Calandra
May 29, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Anthony D HarrisYehuda Carmeli
Jun 5, 2002·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Vladimir KrcmeryPavol Koren
Nov 1, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Aimee K ZaasTrish M Perl
Mar 26, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Stefan ReuterHeike von Baum
Jun 22, 2005·Annals of Internal Medicine·Anat Gafter-GviliLeonard Leibovici
Jul 14, 2005·Scandinavian Journal of Infectious Diseases·Katrin SigurdardottirNina Langeland
Dec 14, 2005·The Journal of Antimicrobial Chemotherapy·Mical PaulLeonard Leibovici
Feb 3, 2006·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M NørgaardH T Sørensen
Jun 21, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kenneth V I RolstonAmar Safdar
Aug 11, 2007·International Journal of Antimicrobial Agents·J KlasterskyM Paesmans
Aug 31, 2007·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·F DrobniewskiUNKNOWN Subcommittee on Antimicrobial Susceptibility Testing of Mycobacterium tuberculosis of the European Committee for Antimicrobi
Oct 7, 2008·Scandinavian Journal of Infectious Diseases·Sari HamalainenE Jantunen
Dec 5, 2009·British Journal of Haematology·Alexandra SmithUNKNOWN Haematological Malignancy Research Network
Oct 14, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ola LandgrenMagnus Björkholm
Mar 1, 2011·Diagnostic Microbiology and Infectious Disease·Heather J AdamUNKNOWN Canadian Antimicrobial Resistance Alliance (CARA)
May 18, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Magnus BjörkholmPaul W Dickman

❮ Previous
Next ❯

Citations

Jan 29, 2013·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·E MontassierM F de La Cochetière
May 17, 2014·Expert Review of Anti-infective Therapy·Carlota Gudiol, Jordi Carratalà
Mar 16, 2016·Annals of Hematology·Christian KjellanderSigurdur Y Kristinsson
Jan 1, 2014·Transplant Infectious Disease : an Official Journal of the Transplantation Society·O BlennowM Remberger
Mar 24, 2016·Virulence·Giulia Gustinetti, Malgorzata Mikulska
Jan 18, 2015·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·E M TrecarichiUNKNOWN HeMABIS Registry—SEIFEM Group, Italy
Dec 20, 2014·Advances in Hematology·Paola Villafuerte-GutierrezCesar Henriquez-Camacho
May 20, 2016·Future Microbiology·Paola Tatarelli, Malgorzata Mikulska
Oct 9, 2014·Current Opinion in Hematology·Małgorzata MikulskaClaudio Viscoli
Sep 11, 2018·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Alzbeta ZavrelovaJakub Radocha
Feb 28, 2014·Current Opinion in Infectious Diseases·Enrico M Trecarichi, Mario Tumbarello
Aug 9, 2020·Frontiers in Microbiology·Rym LalaouiJean-Marc Rolain
Jun 24, 2020·European Journal of Haematology·Vilhjálmur SteingrímssonSigurdur Y Kristinsson
Sep 8, 2020·Expert Review of Anti-infective Therapy·Andrew M PeseskiHeiko Konig
Oct 1, 2020·Expert Review of Hematology·Andrea BacigalupoLivio Pagano

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.