PMID: 8603929Nov 1, 1995Paper

Hematological profile of the euthymic hairless guinea pig following sulfur mustard vesicant exposure

Journal of Applied Toxicology : JAT
M B Gold, B A Scharf

Abstract

Sulfur mustard (HD) is a potent vesicating agent of military importance, with known radiomimetic properties. The euthymic hairless guinea pig (EHGP) (Cavia porcellus) is emerging as the animal model of choice for cutaneous HD study. With elucidation of the systemic effects, we may better utilize this animal for all HD toxicity work. To this end, studies were conducted to determine the definitive median lethal dose (MLD) of subcutaneously applied sulfur mustard (HD) in the EHGP, and to correlate the induced hematological changes. Eight groups of two animals each were dosed at 0.3 log intervals from an extrapolated expected dose, deriving a tentative mean around which five groups of six animals each were dosed at 0.1 log intervals, resulting in a definitive MLD of 48.17 mg kg(-1). Sulfur mustard was then administered to seven groups of six animals each at a dose of 30 mg kg(-1) and hematology performed. Significant leukocyte count suppression was found to occur on days 4, 5 and 6, following a leukocyte elevation on day 1 after exposure. Serum potassium levels were found to be elevated all 7 days after HD exposure. Establishing the MLD for subcutaneously applied HD and the pattern of induced leukocyte suppression allows for more d...Continue Reading

References

Oct 1, 1991·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·J J YourickL W Mitcheltree
Oct 1, 1990·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·M M MershonJ V Wade
Feb 1, 1947·Nature·H CULLUMBINE

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Citations

Feb 1, 1997·Journal of Dermatological Science·K J SmithB E Hackley
Apr 18, 2013·Cutaneous and Ocular Toxicology·Hassan GhasemiTooba Ghazanfari
Mar 22, 2007·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Frances M ReidJohn S Graham
Jul 2, 2017·Journal of Cellular Physiology·Yunes PanahiAmirhossein Sahebkar
Sep 14, 2010·Journal of Applied Toxicology : JAT·Kamyar GhabiliMohammadali M Shoja
Oct 3, 2019·Critical Reviews in Toxicology·Leila EtemadMahdi Balali-Mood
Jun 29, 2001·Journal of Applied Toxicology : JAT·F M ReidJ B Johnson
Nov 24, 2004·Journal of Applied Toxicology : JAT·Mostafa Ghanei

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