Hematopoietic ChemR23 (Chemerin Receptor 23) Fuels Atherosclerosis by Sustaining an M1 Macrophage-Phenotype and Guidance of Plasmacytoid Dendritic Cells to Murine Lesions-Brief Report

Arteriosclerosis, Thrombosis, and Vascular Biology
Emiel P C van der VorstYvonne Döring

Abstract

Objective- Expression of the chemokine-like receptor ChemR23 (chemerin receptor 23) has been specifically attributed to plasmacytoid dendritic cells (pDCs) and macrophages and ChemR23 has been suggested to mediate an inflammatory immune response in these cells. Because chemokine receptors are important in perpetuating chronic inflammation, we aimed to establish the role of ChemR23-deficiency on macrophages and pDCs in atherosclerosis. Approach and Results- ChemR23-knockout/knockin mice expressing eGFP (enhanced green fluorescent protein) were generated and after crossing with apolipoprotein E-deficient ( Apoe-/- ChemR23 e/e) animals were fed a western-type diet for 4 and 12 weeks. Apoe-/- ChemR23 e/e mice displayed reduced lesion formation and reduced leukocyte adhesion to the vessel wall after 4 weeks, as well as diminished plaque growth, a decreased number of lesional macrophages with an increased proportion of M2 cells and a less inflammatory lesion composition after 12 weeks of western-type diet feeding. Hematopoietic ChemR23-deficiency similarly reduced atherosclerosis. Additional experiments revealed that ChemR23-deficiency induces an alternatively activated macrophage phenotype, an increased cholesterol efflux and a syst...Continue Reading

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Citations

Aug 11, 2019·Clinical Science·Kengo SatoTakuya Watanabe
Jul 9, 2020·Frontiers in Immunology·Aslıhan Avanoǧlu GülerMarco Matucci-Cerinic
Jun 14, 2019·Frontiers in Pharmacology·Emiel P C van der VorstYvonne Döring
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Oct 16, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Mitri K KhouryBo Liu
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Jan 19, 2022·Biological Chemistry·Tobias F Fischer, Annette G Beck-Sickinger

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