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Hematopoietic deficiencies in c-mpl and TPO knockout mice

Stem Cells

Jan 1, 1998

M MuroneFrederic J De Sauvage

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Abstract

Thrombopoietin (TPO) is the primary regulatory of megakaryocyte (Meg) and platelet production. Its receptor, c-mpl, is a member of the cytokine receptor superfamily. Major insight into the physiological role of this receptor/ligand pair came from the study of mice carrying disrupted all...read more

Mentioned in this Paper

Anatomical Maturation
Thrombopoietin Measurement
Megakaryocytes
Ligands
Bone Marrow Cells
Hematologic Neoplasms
MPL wt Allele
Platelet Count Measurement
Blood Platelets
Thrombopoiesis
Paper Details
References
    • References25
    • Citations46
    • References25
    • Citations46
  • Hematopoietic deficiencies in c-mpl and TPO knockout mice

    Stem Cells

    Jan 1, 1998

    M MuroneFrederic J De Sauvage

    PMID: 9474742

    DOI: 10.1002/stem.160001

    Abstract

    Thrombopoietin (TPO) is the primary regulatory of megakaryocyte (Meg) and platelet production. Its receptor, c-mpl, is a member of the cytokine receptor superfamily. Major insight into the physiological role of this receptor/ligand pair came from the study of mice carrying disrupted all...read more

    Mentioned in this Paper

    Anatomical Maturation
    Thrombopoietin Measurement
    Megakaryocytes
    Ligands
    Bone Marrow Cells

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    Paper Details
    References
    • References25
    • Citations46
    • References25
    • Citations46
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