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Hematopoietic deficiencies in c-mpl and TPO knockout mice

Stem Cells

Feb 25, 1998

M MuroneF J de Sauvage

Abstract

Thrombopoietin (TPO) is the primary regulatory of megakaryocyte (Meg) and platelet production. Its receptor, c-mpl, is a member of the cytokine receptor superfamily. Major insight into the physiological role of this receptor/ligand pair came from the study of mice carrying disrupted all...read more

Mentioned in this Paper

Thrombocytopenia
Hematologic Neoplasms
Megakaryocytes
Thrombopoiesis
MPL wt Allele
Thrombopoietin Receptor
Biologic Development
Hematopoiesis, Medullary
Etiology
Mice, Knockout
Paper Details
References
  • References25
  • Citations55
123
  • References25
  • Citations55
12345...

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Hematopoietic deficiencies in c-mpl and TPO knockout mice

Stem Cells

Feb 25, 1998

M MuroneF J de Sauvage

PMID: 9474742

DOI: 10.1002/stem.160001

Abstract

Thrombopoietin (TPO) is the primary regulatory of megakaryocyte (Meg) and platelet production. Its receptor, c-mpl, is a member of the cytokine receptor superfamily. Major insight into the physiological role of this receptor/ligand pair came from the study of mice carrying disrupted all...read more

Mentioned in this Paper

Thrombocytopenia
Hematologic Neoplasms
Megakaryocytes
Thrombopoiesis
MPL wt Allele
Thrombopoietin Receptor
Biologic Development
Hematopoiesis, Medullary
Etiology
Mice, Knockout

Similar Papers Found In These Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Related Papers

Biochimica Et Biophysica Acta

Identification and characterization of an isoform of murine Mpl

Biochimica Et Biophysica ActaMay 9, 2002
Diana F SabathVirginia C Broudy
Paper Details
References
  • References25
  • Citations55
123
  • References25
  • Citations55
12345...
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