Hematopoietic failure after hemorrhagic shock is mediated partially through mesenteric lymph

Critical Care Medicine
Dev AnjariaDavid H Livingston


To determine whether hemorrhagic shock-induced bone marrow failure is mediated by the gut through the production of toxic mesenteric lymph and whether shock-induced bone marrow failure could be prevented by division of the mesenteric lymphatics. Prospective, controlled study. University surgical research laboratory. Male Sprague-Dawley rats. Rats were divided into five groups: unmanipulated controls (n = 12), hemorrhagic shock with laparotomy (n = 8), hemorrhagic shock with mesenteric lymph duct ligation (n = 10), sham shock with laparotomy (n = 6), and sham shock with mesenteric lymph duct ligation (n = 7). At either 3 or 6 hrs after resuscitation, bone marrow was obtained for determination of early (cobblestone forming cells) and late (granulocyte-macrophage colony forming unit and erythroid burst forming unit) hematopoietic progenitor cell growth. Parallel cultures were plated with plasma (1% and 2% v/v) from all groups to determine the effect of lymphatic ligation on hematopoiesis. Bone marrow cellularity, cobblestone forming cells, granulocyte-macrophage colony forming unit, and erythroid burst forming unit growth in rats subjected to hemorrhagic with lymph duct ligation were similar to those observed in sham-treated anima...Continue Reading


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Related Concepts

Bone Marrow Failure Syndromes
Entire Duct
Lymphatic Duct
Salicylhydroxamic acid
Colony-Forming Units, Hematopoietic
Hematologic Neoplasms
Bone Marrow
Rats, Sprague-Dawley

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