PMID: 9664165Jul 17, 1998Paper

Hematopoietic growth factors for the treatment of aplastic anemia

Current Opinion in Hematology
M Kumar, B P Alter

Abstract

The use of hematopoietic growth factors, although well established for the management of chemotherapy-induced neutropenia, remains controversial for the treatment of aplastic anemia and inherited bone marrow failure syndromes. The most commonly used factors are granulocyte colony-stimulating factor, granulocyte macrophage colony-stimulating factor, and erythropoietin. Newer growth factors such as stem cell factor, thrombopoietin, Flt3 ligand, and interleukins have shown promising results in the laboratory, and some have been used in clinical trials. This article reviews the clinical use of old and new hematopoietic growth factors in acquired and inherited bone marrow failure, and discusses emerging concerns about long term toxicity of these factors.

Citations

Jul 28, 2005·Annals of Hematology·Michael Heuser, Arnold Ganser
Sep 27, 2003·British Journal of Haematology·Antonio PagliucaUNKNOWN Haemato-Oncology Task Force of the British Committee for Standards in Haematology
Oct 13, 2006·The Veterinary Journal·Emilio Fernández-Varón, Lucía Villamayor
Apr 3, 2001·American Journal of Hematology·Y K KeungD H Buss
Feb 12, 2005·Pediatric Blood & Cancer·Peter KurreH Joachim Deeg
Dec 11, 1999·Current Opinion in Neurology·A J Windebank

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