Feb 1, 1990

Hematopoietic growth factors in cancer

Cancer
M A Moore

Abstract

The family of colony stimulating factors and interleukins influence all aspects of hematopoietic cell proliferation and differentiation. In most instances these hematopoietic growth factors have overlapping, pleiotropic effects and frequently regulate early progenitor cell proliferation and mature cell function. Currently, seven of these factors are in clinical trial: erythropoietin for treatment of anephric anemia, IL-2 in conjunction with LAC therapy, and IL-1, IL-3, G-CSF, GM-CSF, and M-CSF for stimulation of myelopoiesis and granulocyte-macrophage function after chemotherapy, irradiation, or bone marrow transplantation in patients with cancer. G-CSF and GM-CSF have also proved effective in treatment of congenital and idiopathic neutropenias and have had some efficacy in treatment of myeloid leukemias, myelodysplastic disorders, aplastic anemia, and acquired immunodeficiency syndrome (AIDS).

Mentioned in this Paper

Filgrastim
Interleukins
Aplastic Anemia
Antineoplastic Agents
Colony-Stimulating Factors
Neutropenia
IL3 gene
Hematologic Neoplasms
Myelopoiesis
Epoetin Alfa

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