Hematopoietic stem and progenitor cell harvesting: technical advances and clinical utility

Journal of Blood Medicine
Olivier Hequet

Abstract

Hematopoietic stem and progenitor cell (HSPC) transplantations require prior harvesting of allogeneic or autologous HSPCs. HSPCs are usually present in bone marrow (BM) during the entire life, in cord blood (CB) at birth, or in peripheral blood (PB) under particular circumstances. HSPCs were first harvested in BM and later in CB and PB, as studies showed interesting features of such grafts. All harvesting methods were in use throughout the years, except BM harvesting for HSPC autologous transplantation, which was replaced by PB harvesting. BM, CB, and PB harvesting methods have been developed, and materials and devices technically improved to increase the number of HSPCs harvested. In parallel, knowing the features of the donors or patients associated with successful numbers of HSPCs allows the adaptation of appropriate harvesting methods. Moreover, it is important to ensure the safety of donors or patients while harvesting. This review describes the methods used for harvesting based on recent studies or developments around these methods, and more particularly, the means developed to increase the numbers of HSPCs harvested in each method. It also explains briefly the influence of technical improvements in HSPC harvesting on pot...Continue Reading

Citations

Jan 24, 2017·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Véronique DeneysFrançoise Botson
Sep 13, 2019·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Gauruv BoseMark S Freedman
Dec 15, 2015·Cytometry. Part B, Clinical Cytometry·Thomas R CimatoPaul K Wallace
Aug 31, 2016·Transfusion·Kazuhiko IkedaUNKNOWN Study Group for Peripheral Blood Stem Cell Collection, Cell Therapy Committee, The Japan Society of Transfusion Medicine and
Sep 3, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Nopmullee TanhuadKanit Bhukhai

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Methods Mentioned

BETA
cesarean
leukapheresis

Software Mentioned

Spectra Optia
NetCord
COM
COBE

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