Hematopoietic Stem Cell Intracellular Levels of Ca2+ to the Rescue! What Next?

Cell Stem Cell
Hal E Broxmeyer

Abstract

Calcium ions (Ca2+), ubiquitous signaling and second messenger molecules, are communicators for the transmission of messages in numerous cell functions. In this issue of Cell Stem Cell, Luchsinger et al. (2019) provide evidence through the use of transplantation and mechanistic studies for the finding that, "Harnessing Hematopoietic Stem Cell Low Intracellular Calcium Improves Their Maintenance In Vitro."

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