PMID: 7539394Jun 1, 1995Paper

Hematopoietic stem cell markers are expressed by ductal plate and bile duct cells in developing human liver

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
K BlakolmerS C Robson

Abstract

The identification of ductal plate cells as likely progenitors for bile duct epithelium and hepatocytes and their possible reappearance as oval cells in the regenerating liver have generated much interest in their pluripotential capacities. We have examined the distribution of three hematopoietic stem cell markers, c-kit, CD34, and CD33 in addition to laminin, the standard cytokeratin markers CAM 5.2, CK 18, and CK 7 and the oval cell marker OV-6 in fetal liver during various stages of development. Hematopoietic stem cell markers were expressed in ductal plate cells in a pattern similar to the early cytokeratin markers CAM 5.2 and CK 18. Cells stained strongly for these early cytokeratin markers until 22 weeks. Thereafter, the expression of these markers decreased while positivity for CK 7 increased. Bile duct cells showed a distribution of hematopoietic and cytokeratin markers resembling that of ductal plate cells. Both ductal plate cells and bile duct cells expressed OV-6 strongly throughout development. This study showed similarity between hepatic and bile duct precursors and bone marrow stem cells. The comparable distribution of markers in bile duct epithelium and ductal plate cells may imply fewer transitional stages betwe...Continue Reading

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Citations

Oct 2, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H A CrosbyA J Strain
Oct 28, 2005·The American Journal of Pathology·Satdarshan P S MongaJörg C Gerlach
Oct 11, 2008·Tissue Engineering. Part C, Methods·Randall McClellandLola M Reid
Sep 19, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·S BadveR Saxena
Jan 5, 2002·Advances in Anatomic Pathology·Pamela C Gibson, Kumarasen Cooper
Sep 14, 2002·Medical and Pediatric Oncology·Peter Ruck, Jia-Cheng Xiao
Jul 1, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·U BaumannA J Strain
May 17, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Dirk NierhoffDavid A Shafritz
Oct 31, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Lili ZhangLola M Reid
May 6, 2006·Stem Cells·Maggie H Walkup, David A Gerber
May 27, 2004·The American Journal of Pathology·Sandeep S SekhonSatdarshan P S Monga
Dec 8, 2007·Biochemical and Biophysical Research Communications·Natasha WrightDavid A Gerber
Oct 16, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christopher A FrenchJonathan A Fletcher
Jan 1, 2001·Cell Transplantation·Satdarshan P S MongaLopa Mishra
Sep 25, 2018·Journal of Medical Primatology·Natalia Schlabritz-LoutsevitchJerzy Stanek
Nov 19, 2005·Laboratory Investigation; a Journal of Technical Methods and Pathology·Dong-Qi TangLi-Jun Yang
Mar 16, 2002·Blood·Pankaj RajvanshiGeorge B McDonald

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