Hematopoietic Stem Cell Metabolism during Development and Aging

Developmental Cell
Ayako Nakamura-IshizuToshio Suda

Abstract

Cellular metabolism in hematopoietic stem cells (HSCs) is an area of intense research interest, but the metabolic requirements of HSCs and their adaptations to their niches during development have remained largely unaddressed. Distinctive from other tissue stem cells, HSCs transition through multiple hematopoietic sites during development. This transition requires drastic metabolic shifts, insinuating the capacity of HSCs to meet the physiological demand of hematopoiesis. In this review, we highlight how mitochondrial metabolism determines HSC fate, and especially focus on the links between mitochondria, endoplasmic reticulum (ER), and lysosomes in HSC metabolism.

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Citations

Feb 10, 2021·Development·Noelia Urbán, Tom H Cheung
Feb 16, 2021·Stem Cell Reviews and Reports·Hélia FernandesEugénia Carvalho
Feb 27, 2021·Cell Research·Nick van Gastel, David T Scadden
Mar 13, 2021·Blood Advances·Michihiro HashimotoToshio Suda
May 10, 2021·Current Opinion in Hematology·Joydeep GhoshEdward F Srour
Jul 6, 2021·Frontiers in Immunology·Meirong LiXiaobing Fu
Jul 24, 2021·Experimental Hematology·Jean-Pierre LévesqueAllison R Pettit
Jul 25, 2021·Experimental Hematology·Hideaki Nakajima, Koichi Murakami
Sep 23, 2021·Npj Aging and Mechanisms of Disease·Le ZongIsabel Beerman
Oct 30, 2021·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Cornelis J F van NoordenVashendriya V V Hira
Nov 9, 2021·Molecular and Cellular Biology·Shun-Suke SakaiMasaaki Komatsu

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