Hematopoietic stem cell transplantation for multiple sclerosis: is it a clinical reality?

Stem Cell Research & Therapy
Maha M BakhuraysahSteven Petratos

Abstract

Hematopoietic stem cell transplantation (HSCT) is a treatment paradigm that has long been utilized for cancers of the blood and bone marrow but has gained some traction as a treatment paradigm for multiple sclerosis (MS). Success in the treatment of patients with this approach has been reported primarily when strict inclusion criteria are imposed that have eventuated a more precise understanding of MS pathophysiology, thereby governing trial design. Moreover, enhancing the yield and purity of hematopoietic stem cells during isolation along with the utility of appropriate conditioning agents has provided a clearer foundation for clinical translation studies. To support this approach, preclinical data derived from animal models of MS, experimental autoimmune encephalomyelitis, have provided clear identification of multipotent stem cells that can reconstitute the immune system to override the autoimmune attack of the central nervous system. In this review, we will discuss the rationale of HSCT to treat MS by providing the benefits and complications of the clinically relevant protocols, the varying graft types, and conditioning regimens. However, we emphasize that future trials based on HSCT should be focused on specific therapeuti...Continue Reading

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Citations

Aug 10, 2016·Stem Cells and Development·Sharmila FagooneeFiorella Altruda
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Jun 6, 2017·Journal of Neuroscience Research·Heather YongJacqueline Quandt
Jul 27, 2021·Frontiers in Cell and Developmental Biology·Jayden A SmithStefano Pluchino

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Methods Mentioned

BETA
flow cytometry
fluorescence-activated cell sorting
FACS

Software Mentioned

AFFIRM
SENTINEL

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