Feb 1, 1977

Hematopoietic thymocyte precursors: II. Properties of the precursors

The Journal of Experimental Medicine
R S Basch, J L Kadish

Abstract

The properties of hematopoietic cells which serve as the precursors of cortical thymocytes in irradiated reconstituted mice have been described. These cells have been termed "prothymocytes." They are 10- to 15-mum diameter cells of low buoyant density. They are nonadherent to glass wool and more resistant to the lytic effects of steroids and gamma-irradiation than their progeny. They lack detectable amounts of the surface markers associated with either B or T cells but do bear at least two antigens recognized by antisera to mouse brain.

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  • Citations43

Mentioned in this Paper

Centrifugation, Density Gradient
T-Lymphocyte
Colony-Forming Units, Hematopoietic
Spleen
Complement C3 precursor
Receptors, Antigen, B-Cell
Brain
Thymocyte
Immune Sera
Cell Differentiation Process

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