PMID: 3214470Aug 1, 1988Paper

Hematoporphyrin binding to cultured aortic smooth muscle cells from spontaneously atherosclerotic turkey

Atherosclerosis
G ScannapiecoC Dal Palù

Abstract

Porphyrins are known to be accumulated in vivo by tumors and atherosclerotic plaques. We studied the interaction of cultured aortic smooth muscle cells (SMC) from spontaneously atherosclerotic Broad Breasted White Turkeys (BBWT) with free hematoporphyrin (Hp) and low density lipoprotein (LDL)-Hp complexes. A significantly higher binding of LDL-Hp to SMC as compared to free Hp was observed. These data indicate that porphyrin binding to vascular SMC represents a possible mechanism for porphyrin accumulation by atherosclerotic plaques. This process is mediated, at least in part, by LDL.

References

Apr 1, 1986·Circulation Research·S M SchwartzJ H Campbell
Dec 1, 1986·Journal of the American College of Cardiology·A M SpokojnyJ R Spears
Feb 1, 1983·The Journal of Clinical Investigation·J R SpearsS Paulin
Sep 1, 1955·The Journal of Clinical Investigation·R J HAVELJ H BRAGDON

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Citations

Aug 1, 1991·Photochemistry and Photobiology·E DelettreP Peronneau
Mar 1, 1993·Photochemistry and Photobiology·Y N HsiangW E Schreiber

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