PMID: 6276108Mar 1, 1982

Hematoporphyrin derivative and laser photoradiation in the treatment of lung cancer

Chest
Y HayataN Takizawa

Abstract

Photoradiation therapy (PRT) was performed in 13 lung cancer cases and in one case of severely atypical squamous metaplasia following administration of hematoporphyrin derivative (HpD). The HpD is activated by visible red light (630 nm, 90 to 400 mW) from an argon dye laser. The cytocidal effects were due to the activation of the HpD, since 400 mW of power has in itself no effect on normal epithelium, even with long-term exposure. HpD is retained longer by malignant tissue than by normal tissue. Therefore, the lesions were irradiated with the red laser beam, delivered by a quartz fiber inserted through the instrumentation channel of the fiberoptic bronchoscope, 48 hours or more after intravenous injection of 2.5 to 4.0 mg/kg of HpD. A total of 14 cases received PRT. In one, two small, smooth-surfaced, squamous cell carcinoma tumors in the right B2b of a 74-year-old man who had refused surgery disappeared three days after HpD-photoradiation, and the patient remained disease-free 16 months after the treatment. In 12 cases of centrally located lung cancer local effects were obtained in all. However, there was no significant improvement in survival, attributable to the fact that all were advanced-stage cases. One patient with sever...Continue Reading

References

Jan 29, 2003·Journal of Cellular Biochemistry. Supplement·Petra Wilder Smith
Oct 1, 1991·Journal of Surgical Oncology·Y WatanabeK Tanimoto
Jan 8, 2003·Lasers in Surgery and Medicine·Arata EbiharaPetra Wilder-Smith
Jan 1, 1990·Lasers in Surgery and Medicine·J S NelsonM W Berns
Jan 1, 1992·Lasers in Surgery and Medicine·Tetsuya OkunakaK A Koehler
Jan 1, 1995·Lasers in Surgery and Medicine·A M FisherC J Gomer
Jul 1, 1992·Seminars in Surgical Oncology·H I Pass, H Pogrebniak
May 1, 1994·World Journal of Surgery·H D Becker
Jan 1, 1987·Journal of Cancer Research and Clinical Oncology·K KönigH Schubert
Jan 1, 1989·International Journal of Colorectal Disease·H BarrP B Boulos
Nov 1, 1983·World Journal of Surgery·M R Hetzel
Jan 1, 1990·Surgical Endoscopy·Tetsuya OkunakaM L Eckhauser
Jun 23, 2006·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Meike L SchipperSanjiv S Gambhir
Apr 19, 1996·Cancer Letters·K UmemuraS Umemura
Jun 1, 1990·Journal of Photochemistry and Photobiology. B, Biology·J H LiJ Zou
Nov 1, 1990·Journal of Photochemistry and Photobiology. B, Biology·S NakajimaY Shindo
Nov 1, 1990·Journal of Photochemistry and Photobiology. B, Biology·J FeyhE Kastenbauer
Mar 1, 1991·Journal of Photochemistry and Photobiology. B, Biology·S NakajimaH Yamauchi
May 15, 1992·Journal of Photochemistry and Photobiology. B, Biology·N YamamotoT Kimoto
Apr 15, 2004·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Yoshihisa NamikiHiroshi Takahashi
Jun 29, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·H NakamuraH Kato
Sep 27, 2003·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Harubumi KatoHirohisa Horinouchi
May 7, 1998·Cancer Letters·S UmemuraR Nishigaki
Aug 1, 1988·International Journal of Radiation Oncology, Biology, Physics·J W RiekeJ B Mark
May 15, 2002·Journal of Photochemistry and Photobiology. B, Biology·Liming LiKatsuo Aizawa
Nov 1, 1996·Journal of Photochemistry and Photobiology. B, Biology·J Feyh
Nov 1, 1996·Journal of Photochemistry and Photobiology. B, Biology·T G Sutedja, P E Postmus
Apr 16, 1998·Journal of Photochemistry and Photobiology. B, Biology·H Kato
Aug 1, 1987·Annals of Surgery·R J ThomasG Morstyn
Jun 1, 2005·Plastic and Reconstructive Surgery·Cheng-Jen Chang, Petra Wilder-Smith
Oct 1, 1990·Australian and New Zealand Journal of Medicine·R Pierce
Jan 1, 1983·British Medical Journal·M R HetzelI P Williams
Mar 1, 1984·Postgraduate Medical Journal·D P Dhillon, J V Collins
May 1, 1985·Thorax·M R HetzelA M Humberstone
May 1, 1991·Thorax·M R Hetzel, S G Smith

Citations

Sep 1, 1977·Physics in Medicine and Biology·A E Profio, D R Doiron
Oct 1, 1960·Archives of Dermatology·R L LIPSON, E J BALDES
Jul 1, 1948·Proceedings of the Society for Experimental Biology and Medicine·F H J FIGGEL O J MANGANIELLO

Related Concepts

Intravenous Injections
Posterior Ramus of Right Posterior Segmental Bronchus
Neoplasms
Epithelium
Carcinoma of Lung
WR-246310
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Hematoporphyrin Derivative
Carcinoma, Small Cell

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