Hematoporphyrin monomethyl ether enhances the killing action of ultrasound on osteosarcoma in vivo

Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine
Zedan TianWingnang Leung

Abstract

Osteosarcoma is one of the most common malignant cancers afflicting young adults. Ultrasound is a new therapeutic modality for controlling malignant cancers. Enhancing the efficacy of ultrasound treatment will improve clinical outcomes. The aim of this study was to investigate the killing action of ultrasound on osteosarcoma enhanced by hematoporphyrin monomethyl ether (HMME) in vivo. An animal model of an osteosarcoma xenograft was set up to investigate the inhibitory effect of sonoactivating HMME on osteosarcoma. High-performance liquid chromatography was used to analyze the time course of HMME in the osteosarcoma xenograft. Three hours after intravenous (IV) administration of HMME, ultrasound radiation was administered in the osteosarcoma xenograft. On day 7 after ultrasound radiation, the tumor volume and weight were measured and calculated for effect assessment, hematoxylin-eosin staining for histopathologic examination, immunohistochemical staining for proliferating cell nuclear antigen (PCNA) expression, and terminal deoxyuridine nick end-labeling (TUNEL) staining for apoptosis examinations. The peak value of HMME in osteosarcoma tissues increased with time after IV administration of HMME and reached a plateau at 3 hours...Continue Reading

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Citations

Sep 13, 2012·Experimental and Therapeutic Medicine·Xinna WangChuanshan Xu
Sep 26, 2014·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Junyan XiangChuanshan Xu
Aug 13, 2010·Integrative Cancer Therapies·Xinna WangAlbert Wingnang Leung
Oct 15, 2013·Biopharmaceutics & Drug Disposition·Caifeng LiXiaobing Wang
Sep 15, 2012·Experimental and Therapeutic Medicine·Ping WangChuanshan Xu
Mar 16, 2019·Cancers·Valeria CarinaGianluca Giavaresi
Aug 8, 2019·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Yi ZhangXiaojia Huang
Jul 11, 2012·Technology in Cancer Research & Treatment·Zhong-Ye XuZhi-Gang Wang
Aug 3, 2012·International Orthopaedics·Kai ChenMing Li

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