Hematotoxicity and genotoxicity of mercuric chloride following subchronic exposure through drinking water in male rats

Biological Trace Element Research
Mohamed Ali BoujbihaAbdelfattah El Feki

Abstract

Erythrocytes are a convenient model to understand the subsequent oxidative deterioration of biological macromolecules in metal toxicities. The present study examined the variation of hematoxic and genotoxic parameters following subchronic exposure of mercuric chloride via drinking water and their possible association with oxidative stress. Male rats were exposed to 50 ppm (HG1) and 100 ppm (HG2) of mercuric chloride daily for 90 days. A significant dose-dependent decrease was observed in red blood cell count, hemoglobin, hematocrit, and mean cell hemoglobin concentration in treated groups (HG1 and HG2) compared with controls. A significant dose-dependent increase was observed in lipid peroxidation; therefore, a significant variation was found in the antioxidant enzyme activities, such as superoxide dismutase, catalase, and glutathione peroxidase. Interestingly, mercuric chloride treatment showed a significant dose-dependent increase in frequency of total chromosomal aberration and in percentage of aberrant bone marrow metaphase of treated groups (p < 0.01). The oxidative stress induced by mercury treatment may be the major cause for chromosomal aberration as free radicals lead to DNA damage. These data will be useful in screeni...Continue Reading

References

Oct 1, 1992·Free Radical Biology & Medicine·H EsterbauerG Jürgens
Jan 1, 1984·Methods in Enzymology·L Flohé, W A Günzler
Apr 1, 1993·Biological Trace Element Research·I FalnogaP Stegnar
May 1, 1997·Somatic Cell and Molecular Genetics·A N HarveyJ Thacker
Dec 31, 1997·Clinical and Experimental Immunology·A LofteniusE Möller
Sep 5, 1998·Mutation Research·W F MorganB Ponnaiya
Sep 22, 2001·Toxicology in Vitro : an International Journal Published in Association with BIBRA·M AkiyamaM Nakamura
Oct 24, 2001·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·H TapieroD Machover
May 17, 2005·Current Medicinal Chemistry·M ValkoM T D Cronin
Jan 13, 2006·Ecotoxicology and Environmental Safety·Fabíola Raquel Tenório OliveiraDomingos Luiz Wanderley Picanço Diniz
Jan 26, 2006·The Tohoku Journal of Experimental Medicine·Cem Seref BedizEsma Oztekin
Feb 9, 2006·Life Sciences·Rasim MogulkocAbdullah Sivrikaya
Mar 17, 2007·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Eun-Jung Park, Kwangsik Park
Jul 24, 2007·Ecotoxicology and Environmental Safety·Li SuDi-Yun Ruan
Dec 22, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M J Gonzalez-MuñozF J Sánchez-Muniz
Feb 5, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·M Y Burak Cimen
Apr 15, 2008·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Emrah CaylakIhsan Halifeoglu
May 12, 2009·Reproductive Toxicology·Mohamed Ali BoujbihaAbdelfattah El Feki
Sep 1, 2005·Environmental Toxicology and Pharmacology·Mukesh Kumar SharmaAshok Kumar

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Citations

Mar 30, 2013·Aquatic Toxicology·Sofia PytharopoulouDimitrios L Kalpaxis
Jun 21, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Haiyan ZhuXinxin Liu
Sep 11, 2014·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Samira JebahiAbdelfattah El Feki
Feb 6, 2019·Environmental Science and Pollution Research International·Samar S ElblehiYasser S El-Sayed
Nov 6, 2018·Scientific Reports·Mainak GangulyParisa A Ariya
Dec 17, 2019·Environmental Science and Pollution Research International·Rafa S AlmeerAhmed E Abdel Moneim
Aug 24, 2019·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Cuneyt CaglayanMuhammet Bahaeddin Dortbudak

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