PMID: 6021908Mar 3, 1967Paper

Heme and globin synthesis control: observations in vivo in beta thalassemia

Science
M Kreimer-Birnbaum, R M BANNERMAN

Abstract

After administration of glycine-2-(14)C to a patient with thalassemia, the specific activities of heme and globin of F hemoglobin were consistently higher than those of hemoglobin A. After reaching a maximum, the ratio of the specific activity of heme to that of globin remained constant within each hemoglobin. Explanations considered include dilution by preformed subunits, differential turnover of hemoglobins, and possibly more than one heme-synthesizing pool.

References

Dec 11, 1965·Nature·D J WeatherallM A Naughton
Mar 1, 1966·The Journal of Clinical Investigation·A Bank, P A Marks
Mar 1, 1966·Journal of Molecular Biology·B Colombo, C Baglioni
Aug 24, 1966·Biochimica Et Biophysica Acta·P FessasA Kaltsoya
Jun 1, 1961·The Journal of Clinical Investigation·D G NATHANF H GARDNER
Jul 1, 1960·The American Journal of Medicine·M GRINSTEINC V MOORE
Feb 7, 1964·Science·P FESSAS, D LOUKOPOULOS
Jan 18, 1965·Biochemical and Biophysical Research Communications·G P BRUNS, I M LONDON
Mar 1, 1965·Journal of Medical Genetics·E R HUEHNS, E M SHOOTER
Nov 1, 1963·The Journal of Clinical Investigation·T G GabuzdaF H Gardner

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Citations

Jul 1, 1968·British Journal of Haematology·M Kreimer-Birnbaum, R M Bannerman
Feb 1, 1970·British Journal of Haematology·P H PinkertonJ A Edwards

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