PMID: 9434340Jan 22, 1998Paper

Heme availability affects corticosterone and aldosterone biosynthesis in rat adrenal

Steroids
C N MartiniM de C Vila

Abstract

In this paper, we studied the effect of heme availability on corticosterone and aldosterone synthesis in rat adrenal. We found that hemin stimulated corticosterone and aldosterone production in adrenal homogenates in a dose-dependent fashion. Hemin administration to rats also provoked an increase in both corticosterone and aldosterone content in adrenal. 3,5-Diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine (DDC), an inhibitor of liver ferrochelatase activity, was able to inhibit this enzyme in rat adrenal. This resulted in an impairment of heme concentration and consequently adrenal ALA-synthase and porphyrin content were increased. Thus, it was proven that DDC inhibits heme biosynthesis in adrenal as it does in liver. In vivo experiments with rats showed that DDC was able to partially blocked ACTH-mediated corticosterone and aldosterone production while hemin administration was able to partially restore it. These data indicate that heme availability affects steroid biosynthesis in rat adrenal.

References

Mar 1, 1975·Endocrinology·C Gomez-SanchezN M Kaplan
Feb 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·T KawamotoH Imura
Feb 28, 1985·Biochemical and Biophysical Research Communications·F L Bellino, R O Hussa
Sep 1, 1988·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·G S MarksC A James
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Nov 1, 1993·The Journal of Endocrinology·M M Ho, G P Vinson

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Citations

Jul 3, 2015·Endocrine Journal·Tetsuya MizutaniKaoru Miyamoto
Dec 4, 2014·The Journal of Steroid Biochemistry and Molecular Biology·Lina SchifferRita Bernhardt
Jun 1, 2007·Life Sciences·Claudia N MartiniMaría del C Vila

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