PMID: 9177210Jun 10, 1997Paper

Heme compounds in dinosaur trabecular bone

Proceedings of the National Academy of Sciences of the United States of America
Mary Higby SchweitzerJ R Starkey

Abstract

Six independent lines of evidence point to the existence of heme-containing compounds and/or hemoglobin breakdown products in extracts of trabecular tissues of the large theropod dinosaur Tyrannosaurus rex. These include signatures from nuclear magnetic resonance and electron spin resonance that indicate the presence of a paramagnetic compound consistent with heme. In addition, UV/visible spectroscopy and high performance liquid chromatography data are consistent with the Soret absorbance characteristic of this molecule. Resonance Raman profiles are also consistent with a modified heme structure. Finally, when dinosaurian tissues were extracted for protein fragments and were used to immunize rats, the resulting antisera reacted positively with purified avian and mammalian hemoglobins. The most parsimonious explanation of this evidence is the presence of blood-derived hemoglobin compounds preserved in the dinosaurian tissues.

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Citations

Jul 17, 2009·Journal of Proteome Research·Marshall BernDavid Goldberg
Feb 16, 2005·Astrobiology·Mary Higby SchweitzerSeth Pincus
Aug 29, 2007·Astrobiology·Zhiyong SuoMuhammedin Deliorman
May 13, 2005·Proceedings. Biological Sciences·M H SchweitzerS H Pincus
Dec 7, 2006·Proceedings. Biological Sciences·Mary Higby SchweitzerJohn R Horner
Nov 29, 2013·Proceedings. Biological Sciences·Mary H SchweitzerSirine C Fakra
Mar 26, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J L BadaH Hamilton
Nov 5, 2013·Proceedings of the National Academy of Sciences of the United States of America·Derek E G Briggs
Oct 16, 2013·Proceedings of the National Academy of Sciences of the United States of America·Dale E GreenwaltRalph E Harbach
Feb 3, 2015·Journal of Pharmaceutical Sciences·Zhengjie MengYiqiao Hu
Nov 26, 2015·Journal of Proteome Research·Timothy P ClelandMary H Schweitzer
Oct 6, 2015·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Mary H SchweitzerAlison E Moyer
Dec 26, 2001·The Journal of Experimental Zoology·M H Schweitzer, C L Marshall
Dec 11, 2007·Expert Review of Proteomics·Gary B Smejkal, Mary H Schweitzer
Jun 7, 2019·Proteomics·Mary Higby SchweitzerWenxia Zheng
Dec 14, 2019·Expert Review of Proteomics·Brian Thomas, Stephen Taylor
Jan 14, 2020·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Kevin Padian, Armand de Ricqlès
Feb 18, 2004·Systematic Biology·Michel Laurin, Jason S Anderson
Oct 19, 2017·Scientific Reports·Johan LindgrenMary H Schweitzer
Oct 4, 2019·PeerJ·Alida M BailleulMary H Schweitzer
Feb 25, 2021·International Journal of Legal Medicine·Jezerka InkretIrena Zupanič Pajnič
Jun 26, 1998·Analytical Chemistry·L A LyonM J Natan
Mar 26, 2005·Science·Mary H SchweitzerJan K Toporski

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