Heme, iron, and the mitochondrial decay of ageing

Ageing Research Reviews
Hani Atamna

Abstract

Heme, the major functional form of iron, is synthesized in the mitochondria. Although disturbed heme metabolism causes mitochondrial decay, oxidative stress, and iron accumulation, all of which are hallmarks of ageing, heme has been little studied in nutritional deficiency, in ageing, or age-related disorders such as Alzheimer's disease (AD). Biosynthesis of heme requires Vitamin B(6), riboflavin, biotin, pantothenic acid, and lipoic acid and the minerals zinc, iron, and copper, micronutrients are essential for the production of succinyl-CoA, the precursor for porphyrins, by the TCA (Krebs) cycle. Only a small fraction of the porphyrins synthesized from succinyl-CoA are converted to heme, the rest are excreted out of the body together with the degradation products of heme (e.g. bilirubin). Therefore, the heme biosynthetic pathway causes a net loss of succinyl-CoA from the TCA cycle. The mitochondrial pool of succinyl-CoA may limit heme biosynthesis in deficiencies for micronutrients (e.g. iron or biotin deficiency). Ageing and AD are also associated with hypometabolism, increase in heme oxygenase-1, loss of complex IV, and iron accumulation. Heme is a common denominator for all these changes, suggesting that heme metabolism may...Continue Reading

References

Feb 1, 1979·Archives of Biochemistry and Biophysics·D M Bissell, P S Guzelian
Jan 1, 1975·Advances in Experimental Medicine and Biology·G S Wagner, T R Tephly
Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·I J Vincent, P Davies
Feb 1, 1990·Nature·J L Goldstein, M S Brown
Sep 1, 1990·The Journal of Pediatrics·M K GeorgieffJ A Widness
Nov 1, 1986·Journal of Cellular Physiology·J D LaskeyH M Schulman
Aug 1, 1986·Journal of the American Geriatrics Society·D L Marcus, M L Freedman
Apr 1, 1987·Mechanisms of Ageing and Development·M S Bitar, B H Shapiro
Jan 1, 1985·Experimental Gerontology·N G AbrahamM L Freedman
Jan 1, 1985·The British Journal of Nutrition·D M WilliamsB G Green
Jun 1, 1974·Proceedings of the Society for Experimental Biology and Medicine·J S Woods
Nov 1, 1994·Molecular Microbiology·T MogiY Anraku
Jun 1, 1994·Neurology·W D ParkerB K Kleinschmidt-DeMasters
Feb 1, 1993·American Journal of Public Health·R J Stoltzfus, J P Habicht
Feb 1, 1997·Environmental Health Perspectives·W E DaniellG M Franklin
Apr 1, 1996·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·A TodaH Shimeno
Oct 23, 1997·Proceedings of the National Academy of Sciences of the United States of America·L J YanR S Sohal
Dec 12, 1997·FEBS Letters·D HowlettP Camilleri
Jun 20, 1998·The Journal of Biological Chemistry·L S GoesslingR E Thach
Jul 4, 1998·Brain Research. Brain Research Reviews·S H SnyderR Zakhary
Jul 11, 1998·European Journal of Biochemistry·L G NijtmansC Van den Bogert
Jul 17, 1998·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·T KiharaH Shimeno
Jan 30, 1999·The American Journal of Clinical Nutrition·E K HurtadoK G Scott
May 1, 1999·Biochemical and Biophysical Research Communications·Y ZhuL Zhang
Jun 26, 1999·The Journal of Biological Chemistry·H LangeR Lill
Aug 10, 1999·Neuroreport·E A MilwardG A Broe
Oct 16, 1999·The American Journal of the Medical Sciences·P Ponka
Feb 17, 2000·Neurochemistry International·G E GibsonN Y Calingasan
Jul 21, 2000·European Journal of Biochemistry·S TaketaniY Nakahashi

❮ Previous
Next ❯

Citations

Jul 24, 2010·Cell and Tissue Research·Changzheng ZhangTianmiao Hua
Mar 17, 2010·Cardiovascular Toxicology·Ravi Kumar ArvapalliEric R Blough
Jul 24, 2012·Molecular Neurobiology·Kristina LeunerWalter E Müller
Apr 23, 2010·Biochemistry·Gregory P Holmes-HamptonPaul A Lindahl
Feb 24, 2006·Proceedings of the National Academy of Sciences of the United States of America·Hani Atamna, Kathleen Boyle
Oct 20, 2009·Nutrition and Cancer·Daniel PráMichael Fenech
Mar 15, 2011·Cardiovascular Research·Christine Des RosiersJohn C Chatham
Dec 21, 2006·Topics in Magnetic Resonance Imaging : TMRI·John F SchenckTimothy O'Keefe
Aug 28, 2009·Genes & Development·Nan WuMitchell A Lazar
Jun 1, 2012·BMC Systems Biology·Satoshi MizunoHiroshi Tanaka
Nov 2, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Han ZhangHuaxi Xu
Feb 21, 2008·Redox Report : Communications in Free Radical Research·Ashutosh LalBruce N Ames
Oct 18, 2007·Proceedings of the National Academy of Sciences of the United States of America·Benjamin P TuSteven L McKnight
Nov 15, 2006·Proceedings of the National Academy of Sciences of the United States of America·Bruce N Ames
Mar 23, 2011·Journal of Aging Research·Raj Kumar, Hani Atamna
Apr 7, 2007·Digestive Diseases and Sciences·Ioannis StamoulisStamatios Theocharis
Aug 17, 2006·Critical Reviews in Biochemistry and Molecular Biology·Krisztina Z BenczeTimothy L Stemmler
Feb 22, 2012·Mutation Research·Daniel PráMichael Fenech
Dec 15, 2010·International Immunopharmacology·Masahiro IshizukaTohru Tanaka
Aug 7, 2010·Nutrition·Daniel PráSilvia Isabel Rech Franke
Apr 28, 2010·Mechanisms of Ageing and Development·Bruce N Ames
Apr 29, 2009·Biochimica Et Biophysica Acta·Yi-Shing MaYau-Huei Wei
Oct 25, 2008·Biochimica Et Biophysica Acta·Sonia Levi, Ermanna Rovida
Sep 18, 2007·Progress in Neurobiology·Ya Ke, Zhong Ming Qian
Jul 13, 2007·Mitochondrion·Hani Atamna, William H Frey
Dec 1, 2006·Mechanisms of Ageing and Development·Peter J Stambrook
Nov 4, 2004·NMR in Biomedicine·John F Schenck, Earl A Zimmerman
Sep 18, 2007·Journal of Neuroscience Research·Radhika A VaishnavThomas V Getchell
May 16, 2007·Muscle & Nerve·Mikael AltunBrun Ulfhake
Apr 24, 2012·European Journal of Clinical Investigation·Luis García-DizAntonia M Jiménez-Monreal
Aug 25, 2010·Biochimica Et Biophysica Acta·Jaap KeijerYvonne E M Dommels
Jul 4, 2006·Chemico-biological Interactions·Flore DepeintPeter J O'Brien
Jun 13, 2006·Chemico-biological Interactions·Flore DepeintPeter J O'Brien
Jan 8, 2014·Experimental Gerontology·Venkatesh MallikarjunAlberto Sanz
Apr 24, 2014·TheScientificWorldJournal·Daniela SorrientoGuido Iaccarino
Aug 17, 2005·Molecular Aspects of Medicine·Bruce N AmesDavid W Killilea

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aging-Associated Metabolic Disorders

Age is associated with many metabolic disorders including cardiovascular diseases, type 2 diabetes, stroke and heart disease. The mediators in aging process have been suggested to play a part in the cellular processes responsible for these metabolic disorders. Here is the latest research on aging-associated metabolic disorders.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Cell Aging

This feed focuses on cellular aging with emphasis on mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Brain Aging

Here is the latest research on intrinsic and extrinsic factors, as well as pathways and mechanisms that underlie aging in the central nervous system.

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Hani AtamnaBruce N Ames
Proceedings of the National Academy of Sciences of the United States of America
Patrick B WalterBruce N Ames
Current Opinion in Structural Biology
Y Lindqvist, G Schneider
The American Journal of the Medical Sciences
P Ponka
© 2022 Meta ULC. All rights reserved