Heme oxygenase-1 in protozoan infections: A tale of resistance and disease tolerance

PLoS Pathogens
Rafael C M C SilvaMarcelo T Bozza

Abstract

Heme oxygenase (HO-1) mediates the enzymatic cleavage of heme, a molecule with proinflammatory and prooxidant properties. HO-1 activity deeply impacts host capacity to tolerate infection through reduction of tissue damage or affecting resistance, the ability of the host to control pathogen loads. In this Review, we will discuss the contribution of HO-1 in different and complex protozoan infections, such as malaria, leishmaniasis, Chagas disease, and toxoplasmosis. The complexity of these infections and the pleiotropic effects of HO-1 constitute an interesting area of study and an opportunity for drug development.

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Citations

Jan 6, 2021·International Journal of Molecular Sciences·Ayleen Fernández-FierroAlexis M Kalergis
Apr 11, 2021·Nitric Oxide : Biology and Chemistry·Christopher P HopperJakob Wollborn
Aug 15, 2021·Trends in Parasitology·Tiago D SerafimShaden Kamhawi

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