Heme oxygenase-1 is dispensable for the anti-inflammatory activity of intravenous immunoglobulin

Scientific Reports
C GaleottiJagadeesh Bayry

Abstract

Intravenous immunoglobulin G (IVIG) is used in the therapy of various autoimmune and inflammatory conditions. The mechanisms by which IVIG exerts anti-inflammatory effects are not completely understood. IVIG interacts with numerous components of the immune system including dendritic cells, macrophages, T and B cells and modulate their functions. Recent studies have reported that heme oxygenase-1 (HO-1) pathway plays an important role in the regulation of inflammatory response in several pathologies. Several therapeutic agents exert anti-inflammatory effects via induction of HO-1. Therefore, we aimed at exploring if anti-inflammatory effects of IVIG are mediated via HO-1 pathway. Confirming the previous reports, we report that IVIG exerts anti-inflammatory effects on innate cells as shown by the inhibitory effects on IL-6 and nitric oxide production and confers protection in experimental autoimmune encephalomyelitis (EAE) model. However, these effects were not associated with an induction of HO-1 either in innate cells such as monocytes, dendritic cells and macrophages or in the kidneys and liver of IVIG-treated EAE mice. Also, inhibition of endogenous HO-1 did not modify anti-inflammatory effects of IVIG. These results thus ind...Continue Reading

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Citations

Aug 11, 2016·Drug Discovery Today·Caroline GaleottiJagadeesh Bayry
Feb 20, 2018·Immunology·Samanta C FunesAlexis M Kalergis
Apr 5, 2019·Human Vaccines & Immunotherapeutics·Chaitrali SahaJagadeesh Bayry
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Jan 7, 2020·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Jun HagiwaraHiroyuki Yokota
Jul 2, 2017·International Immunology·Caroline GaleottiJagadeesh Bayry
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Apr 27, 2021·Monoclonal Antibodies in Immunodiagnosis and Immunotherapy·Deepak KumarNagendra R Hegde

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Methods Mentioned

BETA
dissection
density gradient centrifugation
lavage
electrophoresis
flow cytometry
ELISA

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