PMID: 16629181Apr 25, 2006Paper

Heme oxygenase 1 overexpression increases iron fluxes in caco-2 cells

Biological Research
M J MendiburoM Arredondo

Abstract

Heme oxygenase-1 is a microsomal enzyme that, when induced by stress, protects the cells from oxidative injury. Heme oxygenase-1 participates in the cleavage of the heme ring producing biliverdin, CO and ferrous Fe. The released Fe becomes part of intracellular Fe pool and can be stored in ferritin or released by an iron exporter. The mechanism by which heme enters cells is not completely understood, although it had been suggested that it might be internalized by an endocytosis process. In this study, we expressed a full-length Heme oxygenase-1 cDNA in Caco-2 cells and measured intracellular iron content, heme-iron uptake and transport and immunolocalization of heme oxygenase-1 in these cells. We found that heme oxygenasc-1 expressing cells showed increased apical heme iron uptake and transepithelial transport when compared to control cells. These results suggested that heme oxygenase-1 mediates heme iron influx and efflux in intestinal cells.

Citations

May 1, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Soichiro TajimaToshiaki Tamaki
Nov 17, 2010·European Journal of Nutrition·M J MendiburoM Arredondo
Dec 13, 2006·FEBS Letters·Gladys O Latunde-DadaAndrew T McKie
Mar 22, 2008·The Journal of Nutrition·Carol D San MartinMarco T Núñez

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