Heme Oxygenase-1 Promotes Delayed Wound Healing in Diabetic Rats

Journal of Diabetes Research
Qingying ChenPing-Ping Zhou

Abstract

Diabetic ulcers are one of the most serious and costly chronic complications for diabetic patients. Hyperglycemia-induced oxidative stress may play an important role in diabetes and its complications. The aim of the study was to explore the effect of heme oxygenase-1 on wound closure in diabetic rats. Diabetic wound model was prepared by making an incision with full thickness in STZ-induced diabetic rats. Wounds from diabetic rats were treated with 10% hemin ointment for 21 days. Increase of HO-1 protein expression enhanced anti-inflammation and antioxidant in diabetic rats. Furthermore, HO-1 increased the levels of VEGF and ICAM-1 and expressions of CBS and CSE protein. In summary, HO-1 promoted the wound closure by augmenting anti-inflammation, antioxidant, and angiogenesis in diabetic rats.

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Citations

Oct 17, 2019·Antioxidants·J Catharina DuvigneauAndrey V Kozlov
Mar 24, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Na-Na ZhuJian-Rong Guo
Feb 22, 2017·International Journal of Molecular Sciences·Niels A J CremersFrank A D T G Wagener
Jul 6, 2019·Naunyn-Schmiedeberg's Archives of Pharmacology·Dhirendra KumarDinesh Kumar
Nov 23, 2018·International Journal of Molecular Sciences·Jun Yeon ParkHye Lim Lee
Jul 13, 2021·Frontiers in Bioengineering and Biotechnology·Wenqian ZhangGuohui Liu

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