Heme-Oxygenase-1

Antioxidants & Redox Signaling
María Marta Facchinetti

Abstract

This Forum issue "Heme Oxygenase" (HO) includes original research articles and reviews that are aimed at understanding the role of HO-1 in several pathophysiological conditions, specially addressing those involving inflammation and oxidative damage. Overall, the seven contributions of this Forum highlight the dual role that HO-1 displays in cells and tissues, and address the molecular and cellular mechanisms through which HO-1 participates in the pathophysiology of the metabolic syndrome, obesity, cancer, and neurodegenerative, neurodevelopmental, and inflammatory bowel diseases. Indeed, one of the reviews thoroughly describes evidence of the anti-inflammatory properties of HO-1 in gut homeostasis, with potential to attenuate inflammatory bowel diseases. Three other reviews show the mostly beneficial effect of HO-1 expression in the attenuation of metabolic syndrome, obesity, cardiovascular disease, and diabetic cardiomyopathy. Contrariwise, one of the original articles show the overexpression of HO-1 in astroglia, models neurodegenerative (Parkinson-like) or neurodevelopmental (Schizophrenia-like) behaviors in mice, depending on the timing of expression of HO-1 during lifespan. The other original research communication demonst...Continue Reading

References

Aug 20, 2019·Archives of Biochemistry and Biophysics·George S DrummondNader G Abraham
Dec 13, 2019·Antioxidants & Redox Signaling·Giulia Marelli, Paola Allavena
Dec 22, 2019·Antioxidants & Redox Signaling·María Victoria MedinaOmar Coso
Dec 28, 2019·Antioxidants & Redox Signaling·Stephen J PetersonJanish Kothari
Jan 1, 2020·Antioxidants & Redox Signaling·Lars BellnerEllen A Thompson

❮ Previous
Next ❯

Citations

Jul 8, 2020·International Journal of Food Sciences and Nutrition·Jialyu HuangYanping Kuang
Sep 26, 2020·International Journal of Molecular Sciences·Jennifer F CarrPhyllis A Dennery

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alternative splicing

Alternative splicing a regulated gene expression process that allows a single genetic sequence to code for multiple proteins. Here is that latest research.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Astrocytes & Neurodegeneration

Astrocytes are important for the health and function of the central nervous system. When these cells stop functioning properly, either through gain of function or loss of homeostatic controls, neurodegenerative diseases can occur. Here is the latest research on astrocytes and neurodegeneration.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Related Papers

Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]
Ajaz Ahmad WazaMusadiq Ahmad Bhat
© 2021 Meta ULC. All rights reserved