Heme oxygenase enzyme activity in seminal plasma of oligoasthenoteratozoospermic males with varicocele

Andrologia
M T Abdel AzizF Waheed

Abstract

This work aimed to assess seminal plasma heme oxygenase (HO) enzyme activity in oligoasthenoteratozoospermia (OAT) males with varicocele. Ninety-three men were divided according to their sperm count and clinical examination into: healthy fertile controls (n = 34), OAT without varicocele (n = 37) and OAT associated with varicocele (n = 22). They were subjected to semen analysis and estimation of seminal plasma HO enzyme activity in the form of bilirubin concentration. Seminal plasma HO enzyme activity decreased significantly in OAT cases compared with controls. Seminal plasma HO in OAT cases associated with varicocele decreased significantly compared with OAT cases without varicocele and healthy controls (mean +/- SD; 109.2 +/- 29.5, 283.6 +/- 88.4, 669.5 +/- 236.1 nMol bilirubin/mg ptn/min, P < 0.001). There was positive correlation between seminal plasma HO enzyme activity and sperm concentration, per cent of motile spermatozoa, number of motile spermatozoas ml(-1) and significant negative correlation with sperm abnormal forms per cent. It is concluded that varicocele has a negative impact on seminal HO enzyme activity. Therefore, improved seminal picture after correcting varicocele repair might be related, in part, to improve...Continue Reading

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Citations

Nov 21, 2012·Nature Reviews. Urology·Alaa HamadaAshok Agarwal
Dec 4, 2012·The Journal of Urology·Adel A ZalataTaymour Mostafa
Mar 20, 2012·The Journal of Urology·Adel A ZalataTaymour Mostafa
Aug 27, 2011·Fertility and Sterility·Adel ZalataTaymour Mostafa
Mar 12, 2016·Journal of Advanced Research·Taymour Mostafa, Mai Taymour
Oct 31, 2018·Andrologia·Abdelshakour A Al-MohammadyYasser A Ghobara
Nov 21, 2012·Nature Reviews. Urology·Ashok AgarwalSandro C Esteves
Jul 8, 2011·Current Opinion in Obstetrics & Gynecology

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