Heme oxygenase exerts a protective role against oxidative stress in soybean leaves

Biochemical and Biophysical Research Communications
Guillermo O NoriegaMaria L Tomaro

Abstract

We have previously demonstrated that the induction of heme oxygenase-1 (EC 1.14.99.3) plays a protective role for mammalian cells against oxidative stress. Here, we investigated for the first time the possible role of heme oxygenase-1 as an antioxidant defense in leaves of soybean plants. Treatment with 200 microM Cd during 48 h caused a 70% increase in thiobarbituric acid reactive substances, whereas GSH decreased 67%, guaiacol peroxidase and total superoxide dismutase also inhibited 49% and 46%, respectively. Two hundred micromolar of Cd produced the overexpression of heme oxygenase-1, as well as a 4.5-fold enhancement of its activity. Administration of biliverdin partially prevented the effects caused by Cd. Pretreatment with Zn protoporphyrin IX, a potent inhibitor of heme oxygenase, expectedly decreased heme oxygenase-1 activity to half. When the inhibitor was given before Cd, it completely prevented the enzyme induction increasing the levels of oxidative stress parameters. Collectively, these results indicated that although plant heme oxygenases share little homology to heme oxygenases from non-plant species, they also play an important protective role against oxidative cell damage.

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Citations

Jun 15, 2007·Planta·Guillermo O NoriegaMaria L Tomaro
Apr 10, 2010·Journal of Experimental Botany·G S Shekhawat, Kusum Verma
Oct 16, 2012·International Journal of Environmental Research and Public Health·Shiyong YangQuanfa Li
Nov 20, 2008·Redox Report : Communications in Free Radical Research·K B BalestrasseM L Tomaro
Jun 20, 2012·Environmental Science and Pollution Research International·Rosaria AcquavivaClaudia Di Giacomo
Feb 5, 2010·International Journal of Cell Biology·Carla Giannina ZilliKarina Beatriz Balestrasse
Jan 12, 2007·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Guillermo O NoriegaMaria L Tomaro
Jan 30, 2008·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Karina B BalestrasseMaria L Tomaro
Sep 17, 2010·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Weiti CuiWenbiao Shen
Oct 28, 2010·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Sheng XuWen-Biao Shen
Aug 14, 2012·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Guillermo NoriegaKarina Beatriz Balestrasse
Oct 20, 2012·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Hua LiZhi Min Yang
Apr 10, 2013·Journal of Plant Physiology·Yun Yen HsuChing Huei Kao
Sep 20, 2012·Journal of Plant Physiology·Yun Yen HsuChing Huei Kao
Jan 31, 2012·Plant Science : an International Journal of Experimental Plant Biology·Bin HanGui-Shui Xie
Nov 6, 2010·Phytochemistry·Karina B BalestrasseGuillermo O Noriega
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Jun 24, 2010·Ecotoxicology and Environmental Safety·Moêz SmiriEzzedine El Ferjani
Dec 17, 2008·Trends in Plant Science·Shanti S Sharma, Karl-Josef Dietz

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