Heme oxygenase microsatellite polymorphism, oxidative stress, glycemic control, and complication development in type 2 diabetes patients

Free Radical Biology & Medicine
Siu-Wai ChoiIris F F Benzie

Abstract

Heme oxygenase-1 (HMOX-1) is activated by oxidative stress, and gene responsiveness is reportedly determined by the number of dinucleotide (GT(n)) repeats in its highly polymorphic promoter region. "Short" (S; GT(n)<25) alleles reportedly associate with higher response, lower oxidative stress, lower risk of type 2 diabetes mellitus (type 2DM), and better glycemic control and outcome, but data are conflicting. We investigated GT(n) in type 2DM subjects (all ethnic Chinese) in relation to basal glycemic control, oxidative stress, and outcome during up to 9 years' follow-up. Fasting blood from 418 type 2 DM subjects was collected at entry for GT(n) genotyping, glycated hemoglobin, glucose, lipids, and biomarkers of oxidative stress and antioxidants. A subset (n=368) was followed for up to 9 years for incident complications or death. GT(n) genotype distribution was 128, 182, and 108 for, respectively, S/S, S/L, and L/L. No significant differences in glycemic control, lipids, or oxidative stress were seen across genotypes. During follow-up, 168/368 subjects developed complications. No association was seen with GT(n). No difference in plasma HO-1 was seen between genotypes in a small substudy (S/S n=21 vs L/L n=23). Glycated hemoglob...Continue Reading

References

Sep 29, 2004·Free Radical Biology & Medicine·Markus ExnerMartin Schillinger
Jun 1, 2005·Free Radical Biology & Medicine·Nader G Abraham, Attallah Kappas
Feb 2, 2006·Diabetes, Obesity & Metabolism·L E Fridlyand, L H Philipson
Apr 8, 2006·Physiological Reviews·Stefan W RyterAugustine M K Choi
Sep 13, 2008·Journal of the American College of Cardiology·Naglaa K IdrissGregory Y H Lip
Jan 24, 2009·Trends in Molecular Medicine·Miguel P Soares, Fritz H Bach
Aug 22, 2009·American Journal of Epidemiology·Fangfang SongLiegang Liu
Jan 14, 2011·Diabetes Care·UNKNOWN American Diabetes Association

❮ Previous
Next ❯

Citations

Nov 5, 2013·Antioxidants & Redox Signaling·Louise L DunnRoland Stocker
Feb 6, 2014·Journal of Endocrinological Investigation·S I Al-AzzamA Y Alhasan
Apr 2, 2015·European Heart Journal·Laura E FredenburghSusan Cheng
May 13, 2014·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Melissa A AllwoodJeremy A Simpson
Jul 31, 2016·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Mónica AndrewsMiguel Arredondo-Olguín

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.