Heme oxygenase modulates hepatic leukocyte sequestration via changes in sinusoidal tone in systemic inflammation in mice

Microvascular Research
Christian WunderRichard F Potter

Abstract

Heme oxygenase (HO) modulates the accumulation of leukocytes within the liver during the early stages of a systemic inflammatory response syndrome (SIRS), but the anti-inflammatory mechanism(s) remain to be tested. The influence of HO on the adhesion molecule expression within the liver and on circulating leukocytes was assessed. In addition, the effect of HO and nitric oxide synthase (NOS) on the liver microcirculation was tested. Mice were subjected to 1 h bilateral hindlimb ischemia followed by 3 h of reperfusion, at which time blood samples and the liver were harvested and adhesion molecule expression determined (ICAM-1, CD49d and CD11b). Direct measures of sinusoidal diameter and estimates of volumetric blood flow were obtained using intravital microscopy. HO was specifically induced and inhibited by hemin and chromium mesoporphyrin (CrMP), respectively, whereas NOS was inhibited by N-nitro-L-arginine methyl ester (L-NAME). ICAM-1 expression was increased following hindlimb ischemia-reperfusion. Hemin caused only a modest, but significant decrease in ICAM-1 expression, whereas inhibition of HO had no effect. However, HO inhibition significantly reduced sinusoidal diameters and volumetric flow and such vessels were correlat...Continue Reading

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Citations

Jul 11, 2009·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Niteen TapuriaBrian R Davidson
Jan 16, 2016·BioMed Research International·Kristina L GoJae-Sung Kim
Sep 7, 2012·Journal of Proteomics·Virginia Sánchez-QuilesFernando J Corrales
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Feb 7, 2006·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Alison A DungeyRichard F Potter
Dec 13, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Robert B DormanRobert W Brock
Mar 8, 2008·Pharmacological Reviews·Nader G Abraham, Attallah Kappas
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Mar 1, 2005·American Journal of Physiology. Heart and Circulatory Physiology·László SzalayIrshad H Chaudry

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