Hemibody irradiation (HBI) for metastatic bone pain in two histologically distinct groups of patients

Clinical Oncology : a Journal of the Royal College of Radiologists
P J HoskinC L Harmer

Abstract

Fifty patients with hemibody irradiation (HBI) for metastatic bone pain have been reviewed. A total of 60 treatments were given (9 upper HBI, 31 lower HBI and 10 both upper and lower HBI). Seventeen patients had metastatic myeloma and 30 had metastatic prostatic carcinoma. The overall response rate was 83% with a 5% complete response rate. Response was seen within 24 hours in 25% of treatments and lasted until death in 74%. No difference in the response characteristics was seen between those patients with myeloma and those with prostatic carcinoma. Significant toxicity occurred in 60% of patients, predominantly gastrointestinal toxicity and bone marrow suppression. One case of fatal pneumonitis occurred. The possibility of maintaining these response rates but reducing toxicity using lower doses of HBI is discussed.

References

Nov 1, 1985·International Journal of Radiation Oncology, Biology, Physics·G M Duchesne, C L Harmer
Aug 1, 1986·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·P PriceJ R Yarnold
Mar 1, 1973·The American Journal of Roentgenology, Radium Therapy, and Nuclear Medicine·E L SaengerB I Friedman
Mar 1, 1981·Clinical Radiology·M M Qasim
Dec 1, 1981·British Journal of Urology·C G RowlandJ B Roberts
Dec 1, 1984·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J DeaconG G Steel

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Citations

Jan 1, 1993·European Journal of Nuclear Medicine·V J Lewington
Jan 19, 2008·Medical Oncology·A Ugur UralYusuf Baran
Dec 1, 1994·International Journal of Radiation Oncology, Biology, Physics·A N Serafini
Jan 10, 1998·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·M N GazeA Rodger
May 23, 2001·Journal of Pain and Symptom Management·M A del RosarioM Feria
Mar 31, 1999·Journal of Pain and Symptom Management·R DawsonM B Barton
Nov 27, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J Davis, R J Pither
Sep 19, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R D Rubens
Oct 26, 1999·Critical Reviews in Oncology/hematology·T A Plunkett, R D Rubens
Jul 5, 2001·Breast Cancer Research and Treatment·R SciutoC L Maini
Nov 23, 1991·BMJ : British Medical Journal·C G KellyA Rodger
Sep 2, 2011·The Oncologist·William IrvinDeborah K Mayer
Aug 1, 1991·Journal of Pain and Symptom Management·M Ashby
Jan 1, 1991·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P J Hoskin
Jun 1, 1991·Blood Reviews·N P Rowell, J S Tobias
Mar 1, 1992·Clinical Oncology : a Journal of the Royal College of Radiologists·D P DearnaleyV J Lewington
Jun 20, 2008·Clinical Oncology : a Journal of the Royal College of Radiologists·F A BashirP M Windsor
Mar 10, 2001·Journal of Evaluation in Clinical Practice·M B BartonG Morgan
Jan 1, 1996·Acta Oncologica·R G Parker
Jan 1, 1994·Palliative Medicine·P R Needham, P J Hoskin
Jul 15, 2015·Therapeutic Advances in Urology·Jim N Rose, Juanita M Crook
Oct 1, 1996·Physics in Medicine and Biology·M N Gaze
Oct 1, 1996·Physics in Medicine and Biology·V J Lewington
Nov 1, 1995·Pain·P J Hoskin
Aug 27, 2002·Nuclear Medicine Communications·V J Lewington
May 25, 2002·The American Journal of Hospice & Palliative Care·Perry G Fine
Dec 16, 2006·Clinical Oncology : a Journal of the Royal College of Radiologists·J P AgarawalP J Hoskin
Dec 4, 2012·Chemical Reviews·Cathy S CutlerSilvia S Jurisson

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