PMID: 2485880Oct 23, 1989Paper

Hemicholinium-3-resistant choline uptake system linked to acetylcholine synthesis in the rat hippocampus

Neuroscience Letters
T SuzukiK Kawashima

Abstract

Extracellular choline-dependency of acetylcholine (ACh) synthesis was examined in rat hippocampal slices. In the presence of hemicholinium-3 (HC-3, 5 microM), extracellular choline-dependent ACh synthesis appeared to consist of two different components. The first component (saturated at up to 50 microM choline) was dependent on the HC-3-resistant choline uptake system having a low capacity for choline in comparison with the high-affinity choline uptake system (HACU). The second component, observed in the presence of more than 50 microM choline, was considered due to competitive inhibition of HACU by HC-3. HACU-dependent ACh synthesis seemed to be saturated in the presence of up to 2 microM choline. These results indicate that both the HACU and HC-3-resistant choline uptake systems are linked to ACh synthesis in the hippocampus.

References

Jan 1, 1985·Journal of Neurochemistry·S Tucek
Jan 1, 1984·Progress in Biophysics and Molecular Biology·S Tucek
Aug 12, 1983·Science·J K Blusztajn, R J Wurtman
Feb 1, 1980·Journal of Pharmacological Methods·K KawashimaM Mochizuki

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