Hemichorea associated with gabapentin therapy with hypoperfusion in contralateral basal ganglion - a case of a paraplegic patient with neuropathic pain

Journal of Clinical Pharmacy and Therapeutics
M-H LaiS-T Chang

Abstract

Functional imaging in patients with movement disorders has suggested abnormalities of regional cerebral blood flow (rCBF). We describe a patient with thoracic cord lesion with subsequent severe neuropathic pain. Right hemichorea developed and was related to adjunctive therapy with gabapentin. The patient's hemichorea decreased gradually after cessation of gabapentin. The study of rCBF revealed hypoperfusion in the contralateral basal ganglia compared with the previous study of rCBF. Our patient is the first patient with neuropathic pain, treated with gabapentin who developed hemichorea, in the absence of brain lesions. Imaging studies of rCBF showed a perfusion defect in the contralateral basal ganglion.

References

Jul 1, 1992·Acta Radiologica·M H LiE M Larsson
Jul 1, 1990·Trends in Neurosciences·G E Alexander, M D Crutcher
Mar 1, 1987·Archives of General Psychiatry·M J Garvey, G D Tollefson
Aug 1, 1994·Brain : a Journal of Neurology·K P Bhatia, C D Marsden
Feb 24, 1994·The New England Journal of Medicine·J F Ditunno, C S Formal
Apr 11, 2000·Epilepsia·J AsconapéJ DellaBadia
Jun 11, 2005·European Journal of Nuclear Medicine and Molecular Imaging·Eun Yeon JooByung Tae Kim

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Citations

Sep 14, 2010·Journal of Clinical Pharmacy and Therapeutics·Y-T WuS-T Chang
Sep 12, 2013·Pain·Luis Garcia-Larrea, Roland Peyron
Mar 22, 2016·Yonsei Medical Journal·Hyun Chang LeeSuk Yun Kang
Dec 3, 2013·Journal of Neural Transmission·Angelo FranziniDario Caldiroli
Jan 27, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Francisco Martínez-DubarbieJon Infante

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