Hemiparesis, encephalopathy, and extrapontine osmotic myelinolysis in the setting of hyperosmolar hyperglycemia

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
Waldo R GuerreroStephen E Nadeau

Abstract

Osmotic demyelination syndrome (ODS) is a recognized complication of rapid correction of hyponatremia. However, other medical conditions have been associated recently with the development of ODS in the absence of changes in serum sodium. We present a 23-year-old man who developed left hemiparesis and encephalopathy after treatment of hyperglycemia. MRI demonstrated changes in the splenium of the corpus callosum and the posterior limb of the right internal capsule. This report, together with others, suggests that the full spectrum of lesions of ODS, pontine and extrapontine, can occur in the setting of any rapid change in osmolar state.

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Citations

Jun 4, 2013·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Halil OnderMehmet Akif Topcuoglu
Feb 25, 2014·Journal of Neurology, Neurosurgery, and Psychiatry·Dimitri RenardGuillaume Taieb
Dec 3, 2014·Neurología : publicación oficial de la Sociedad Española de Neurología·J A Matías-GuiuM Ruiz-Yagüe
Nov 29, 2014·Case Reports in Neurological Medicine·Karla Victoria Rodríguez-VelverRené Rodríguez-Gutiérrez
Nov 10, 2013·The Journal of Emergency Medicine·Azeemuddin AhmedAmy Engelman
Apr 29, 2015·Singapore Medical Journal·Monica SainiRajinder Singh
Dec 10, 2020·Clinical Diabetes and Endocrinology·Koshi KusumotoYoshihiko Nishio
Mar 18, 2021·Curēus·Mojgan JalalzadehDonald Baumstein

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