Hemisphere Asymmetry of Response to Pharmacologic Treatment in an Alzheimer's Disease Mouse Model

Journal of Alzheimer's Disease : JAD
Antigoni ManousopoulouSpiros D Garbis

Abstract

The aim of this study was to examine hemisphere asymmetry of response to pharmacologic treatment in an Alzheimer's disease mouse model using cilostazol as a chemical stimulus. Eight-month-old mice were assigned to vehicle or cilostazol treatment for three months and hemispheres were analyzed using quantitative proteomics. Bioinformatics interpretation showed that following treatment, aggregation of blood platelets significantly decreased in the right hemisphere whereas neurodegeneration significantly decreased and synaptic transmission increased in the left hemisphere only. Our study provides novel evidence on cerebral laterality of pharmacologic activity, with important implications in deciphering regional pharmacodynamic effects of existing drugs thus uncovering novel hemisphere-specific therapeutic targets.

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Citations

Nov 2, 2016·European Journal of Clinical Investigation·Nasser M Al-DaghriSpiros D Garbis
Nov 8, 2018·Doklady Biological Sciences : Proceedings of the Academy of Sciences of the USSR, Biological Sciences Sections·A A OrlovS V Afanasyev

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Methods Mentioned

BETA
transgenic

Clinical Trials Mentioned

NCT02491268

Software Mentioned

Gene Cluster
R
BioConductor
Java Treeview
SequestHT
Proteome Discoverer

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