Hemispherectomy for intractable seizures: presurgical cerebral glucose metabolism and post-surgical non-verbal communication

Developmental Medicine and Child Neurology
R CaplanP Mundy

Abstract

This study examined the presurgical 2-deoxy-2[18F]-fluoro-D-glucose positron emission tomography (PET) patterns of regional cerebral glucose metabolism in the non-resected hemisphere of 13 children who underwent hemispherectomy for early-onset intractable seizures. These patterns were compared with the rate of change in the children's non-verbal communication scores, measured before and after surgery. Irrespective of the side of surgery, the pre-operative glucose metabolism in the non-resected prefrontal cortex correlated significantly with the postoperative rate of change in the children's ability to focus the attention of an adult on an object or event (joint attention). These preliminary findings suggest that pre-operative PET patterns might be associated with certain aspects of the developmental outcome of children undergoing hemispherectomy.

References

Aug 1, 1977·Archives of Neurology·D M Bear, P Fedio
Jun 1, 1992·Developmental Medicine and Child Neurology·R CaplanW J Peacock
Jan 1, 1991·Progress in Brain Research·J M Fuster
May 1, 1991·Epilepsia·D B LeidermanW H Theodore
Nov 1, 1990·Pediatric Neurology·R J KonkolJ R Sty
Mar 1, 1990·Journal of Autism and Developmental Disorders·P MundyC Kasari
May 1, 1989·Annals of Neurology·W H TheodoreL Onorati
Jan 1, 1988·Epilepsia·W H Theodore
Mar 1, 1988·The International Journal of Neuroscience·R J Davidson
Oct 1, 1987·Annals of Neurology·H T ChuganiJ C Mazziotta
Sep 1, 1986·Journal of Autism and Developmental Disorders·K A Loveland, S H Landry
Sep 1, 1987·Journal of Autism and Developmental Disorders·P MundyT Sherman
Apr 1, 1986·Annals of Neurology·M M Mesulam
Sep 1, 1986·Journal of Child Psychology and Psychiatry, and Allied Disciplines·M SigmanJ Ungerer
Apr 1, 1983·Archives of Neurology·D M Bear
May 1, 1983·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·T Rasmussen
Jul 1, 1983·Journal of Neurology, Neurosurgery, and Psychiatry·C B Adams
Nov 1, 1950·Journal of Neurology, Neurosurgery, and Psychiatry·R A KRYNAUW

❮ Previous
Next ❯

Citations

Oct 19, 2004·Development and Psychopathology·Stephen J SheinkopfJennifer Willoughby
Mar 3, 2007·The European Journal of Neuroscience·Tobias Grossmann, Mark H Johnson
Feb 1, 1996·Journal of Child Psychology and Psychiatry, and Allied Disciplines·C Hughes
Jun 29, 2006·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Jean-Guy Villemure, Roy Thomas Daniel
Sep 10, 2003·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Peter Mundy
Jan 8, 2017·Cerebral Cortex·Adam T EggebrechtJohn R Pruett
Aug 15, 2002·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Lynnette M HendersonAndrea McDuffie

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.