PMID: 9432160Feb 12, 1998Paper

Hemispheric language dominance studied with functional MR: preliminary study in healthy volunteers and patients with epilepsy.

AJNR. American Journal of Neuroradiology
B F van der KallenV M Haughton

Abstract

We used functional MR imaging to compare hemispheric language dominance in healthy volunteers and in patients with epilepsy. We retrospectively reviewed the functional MR images of 23 healthy volunteers and 16 patients with epilepsy obtained by using an echo-planar technique designed for whole-brain imaging. The activation paradigm used was a silent word generation task. Hemispheric language dominance was assessed as the percentage of activated pixels in the left hemisphere minus the percentage of activated pixels in the right hemisphere x 100. We found no significant difference in language lateralization between right-handed male and right-handed female volunteers. However, a statistically significant difference in language distribution was found between left- and right-handed female volunteers. The left-handed female volunteers showed a more bilateral hemispheric language lateralization. Language lateralization in right-handed male epilepsy patients with early age at seizure onset and seizure locus in the left temporal lobe was not significantly different from that of healthy right-handed male volunteers. Similarly, we found no difference in language lateralization between right-handed female volunteers and right-handed femal...Continue Reading

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