Hemithyroidectomy: the preferred initial surgical approach for management of Hurthle cell neoplasm

American Journal of Surgery
A MelckSam M Wiseman

Abstract

The objective of this study was to evaluate the cancer risk of patient clinicopathologic characteristics to determine the optimal approach for the surgical management of individuals with Hurthle cell neoplasm (HN) diagnosed by cytology. Patient clinicopathologic characteristics evaluated included age, sex, tumor size, and ipsilateral thyroid lobe nodularity. The association of these characteristics with a pathologic cancer diagnosis was evaluated using Fisher's exact test and Student t test. Of the 422 patients undergoing thyroidectomy, 27 presented with a fine-needle aspiration biopsy diagnosis of HN, and by pathologic assessment 7 HN patients (25.9%) had a cancer diagnosis. Although none of the clinicopathologic characteristics evaluated were able to reliably differentiate benign from malignant tumors, large tumor size and male sex were significantly associated with a pathologic diagnosis of Hurthle cell carcinoma (P < .05). Hemithyroidectomy represents the preferred initial surgical approach for the management of individuals presenting with nodular thyroid disease and a cytologic diagnosis of HN.

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Citations

Sep 21, 2007·Annals of Surgical Oncology·Adrienne MelckSam M Wiseman
Jul 31, 2008·Annals of Surgical Oncology·Yi Wei ZhangHerbert Chen
May 29, 2012·Canadian Journal of Surgery. Journal Canadien De Chirurgie·Connie G ChiuSam M Wiseman
Jan 29, 2008·World Journal of Surgery·Rebecca S SippelOrlo H Clark
May 16, 2013·Current Problems in Surgery·Judy JinChristopher R McHenry
Apr 22, 2008·American Journal of Surgery·Sam M WisemanSteven J M Jones
Apr 7, 2010·The American Journal of Pathology·Connie G ChiuSam M Wiseman
May 18, 2016·The Indian Journal of Surgery·Michael Shawky, Mahmoud Sakr
Jul 29, 2016·Hormone Research in Pædiatrics·Elna KochummenVivian L Chin
Sep 2, 2008·Expert Review of Anticancer Therapy·Obi L GriffithSam M Wiseman
May 4, 2018·Acta Cytologica·Cristina Díaz Del Arco, M Jesús Fernández Aceñero
Apr 22, 2008·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Zeev V MaizlinJacqueline A Brown

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