PMID: 6167551Dec 1, 1980Paper

Hemizygous HLA mutants of lymphoblastoid cells: a new cell type for histocompatibility testing

Human Immunology
P KavathasF H Bach

Abstract

HLA variants that have lost expression of multiple cis-linked alleles as determined serologically and enzymatically were analyzed for expression of HLA-D PLT-stimulating (PL) determinants using the primed lymphocyte test. All 19 variants that had lost HLA-DRw3 expression simultaneously had lost expression of the HLA-D region-associated PL specificity. PLT cells made by priming to a variant that was hemizygous for HLA genes resulted in priming to HLA-D PL determinants encoded for by just one haplotype, analogous to priming to an HLA homozygous cell.

References

Jan 1, 1977·Scandinavian Journal of Immunology·F H BachM L Bach
Dec 1, 1978·The Journal of Experimental Medicine·R TosiD Pressman
Apr 13, 1978·Nature·C G Fathman, H Hengartner
Nov 1, 1978·Tissue Antigens·M J Healy
May 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·D PiousG Forrest
Jul 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·P KavathasR DeMars

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Citations

Nov 1, 1986·Somatic Cell and Molecular Genetics·N NadonR DeMars
Dec 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·R DeMarsH T Orr
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·R LeachR White
Feb 1, 1989·The Journal of Experimental Medicine·B H KollerH T Orr
Aug 26, 1998·Tissue Antigens·G DíazJ Arroyo
Apr 28, 2004·Cytokine & Growth Factor Reviews·Endre Kiss-TothSteven K Dower
Jul 3, 1983·Nature·A J WatsonF H Bach
Jan 1, 1985·Rheumatology International·C A PapasteriadesH M Moutsopoulos
Jan 1, 1988·Scandinavian Journal of Rheumatology. Supplement·J H VaughanG H Rhodes
Nov 26, 2002·Tissue Antigens·W T N SwelsenE M van den Berg-Loonen

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