Hemoadsorption treatment of patients with acute infective endocarditis during surgery with cardiopulmonary bypass - a case series

The International Journal of Artificial Organs
Karl TrägerHelmut Reinelt

Abstract

Infective endocarditis is a serious disease condition. Depending on the causative microorganism and clinical symptoms, cardiac surgery and valve replacement may be needed, posing additional risks to patients who may simultaneously suffer from septic shock. The combination of surgery bacterial spreadout and artificial cardiopulmonary bypass (CPB) surfaces results in a release of key inflammatory mediators leading to an overshooting systemic hyperinflammatory state frequently associated with compromised hemodynamic and organ function. Hemoadsorption might represent a potential approach to control the hyperinflammatory systemic reaction associated with the procedure itself and subsequent clinical conditions by reducing a broad range of immuno-regulatory mediators. We describe 39 cardiac surgery patients with proven acute infective endocarditis obtaining valve replacement during CPB surgery in combination with intraoperative CytoSorb hemoadsorption. In comparison, we evaluated a historical group of 28 patients with infective endocarditis undergoing CPB surgery without intraoperative hemoadsorption. CytoSorb treatment was associated with a mitigated postoperative response of key cytokines and clinical metabolic parameters. Moreover,...Continue Reading

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Citations

Oct 17, 2018·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Martin H BernardiMichael J Hiesmayr
Dec 24, 2019·The International Journal of Artificial Organs·Karl TrägerThomas Datzmann
Jun 26, 2020·Medizinische Klinik, Intensivmedizin und Notfallmedizin·C G Krenn, H Steltzer
Nov 18, 2018·Intensive Care Medicine·Elettra C PoliAntoine G Schneider
Apr 5, 2019·Critical Care : the Official Journal of the Critical Care Forum·Elettra C PoliAntoine G Schneider
Feb 26, 2019·The International Journal of Artificial Organs·Lars-Uwe KühneFriedrich-Christian Rieß
Nov 7, 2019·Critical Care : the Official Journal of the Critical Care Forum·Sébastien RedantPatrick M Honore
Jul 19, 2018·Case Reports in Critical Care·Francesca LeonardisGaetano La Manna
Jun 27, 2019·The International Journal of Artificial Organs·Silvius FrimmelSebastian Koball
Feb 10, 2018·Case Reports in Critical Care·Heinz SteltzerReinhard Berger
Aug 15, 2019·Intensive Care Medicine·Miet Schetz, Thomas Bein
Jun 4, 2020·Journal of the Intensive Care Society·Klaus KogelmannDominik Jarczak
Feb 10, 2021·Journal of Medical Case Reports·Fabio Silvio TacconeDavid Grimaldi
Feb 16, 2020·The Annals of Thoracic Surgery·Zaki HaidariMohamed El-Gabry
Apr 7, 2020·The Thoracic and Cardiovascular Surgeon·Ali AkilStefan Fischer
Apr 22, 2021·Journal of Cardiothoracic Surgery·Alina ZubarevichAlexander Weymann
Feb 16, 2021·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Daniel ZicklerJan Matthias Kruse
Oct 26, 2021·Artificial Organs·Konstantin ZhigalovAlexander Weymann

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Software Mentioned

Cytosorb
GraphPad Prism

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