Hemochromatosis: Evaluation of the dietary iron model and regulation of hepcidin

Biochimica Et Biophysica Acta. Molecular Basis of Disease
Gautam RishiV Nathan Subramaniam

Abstract

Our knowledge of iron homeostasis has increased steadily over the last two decades; much of this has been made possible through the study of animal models of iron-related disease. Analysis of transgenic mice with deletions or perturbations in genes known to be involved in systemic or local regulation of iron metabolism has been particularly informative. The effect of these genes on iron accumulation and hepcidin regulation is traditionally compared with wildtype mice fed a high iron diet, most often a 2% carbonyl iron diet. Recent studies have indicated that a very high iron diet could be detrimental to the health of the mice and could potentially affect homeostasis of other metals, for example zinc and copper. We analyzed mice fed a diet containing either 0.25%, 0.5%, 1% or 2% carbonyl iron for two weeks and compared them with mice on a control diet. Our results indicate that a 0.25% carbonyl iron diet is sufficient to induce maximal hepatic hepcidin response. Importantly these results also demonstrate that in a chronic setting of iron administration, the amount of excess hepatic iron may not further influence hepcidin regulation and that expression of hepcidin plateaus at lower hepatic iron levels. These studies provide furth...Continue Reading

Citations

Dec 7, 2018·Future Medicinal Chemistry·Agata Gitlin-DomagalskaKrzysztof Rolka
Aug 9, 2020·Bioscience Reports·Gautam RishiV Nathan Subramaniam
Sep 11, 2019·The Journal of Nutrition·Xiaoyu WangJames F Collins
Oct 11, 2020·Biomolecules·Karolina KrzywoszyńskaHenryk Kozłowski

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