Hemochromatosis in Italy in the last 30 years: role of genetic and acquired factors

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Anna Ludovica FracanzaniSilvia Fargion

Abstract

The clinical presentation of hereditary hemochromatosis has changed markedly in recent years. The aim of this study was to analyze a large series of consecutive Italian patients with hemochromatosis diagnosed between 1976 and 2007 to determine whether the genetic background and the presence of acquired risk factors influenced the severity of iron overload and the natural history of the disease. A cohort of 452 Italian patients with iron overload-338 HFE-related (C282Y homozygotes or compound C82Y/H63D heterozygotes) and 114 non-HFE-related-were followed prospectively for a median of 112 months. Alcohol intake, smoking habits, and iron removed to depletion were similar in patients with and without HFE-related iron overload. Hepatitis B virus (4% and 9%; P = 0.04) and hepatitis C virus (6% and 19%; P = 0.002) infections were more frequent in patients with non-HFE-related iron overload. Seventy-three percent of patients with HFE and 61% of patients with non-HFE-related disease had no acquired risk factor. Cirrhosis was significantly more frequent in non-HFE patients independent of the presence of acquired risk factors (P = 0.02). Sex, alcohol intake, prevalence of smoking, hepatitis C virus infection, glucose, lipids, iron-related...Continue Reading

References

Apr 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S FargionD Conte
May 1, 1992·American Journal of Epidemiology·R D'AmelioP Pasquini
Apr 1, 1996·Gastroenterology·C NiederauG Strohmeyer
Jan 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P C AdamsP Brissot
Jan 13, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M SampietroS Fargion
May 30, 1998·Gastroenterology·A PipernoC Camaschella
Jun 23, 1999·The American Journal of Medicine·S M McDonnellR Yip
Sep 2, 1999·The New England Journal of Medicine·J K OlynykL W Powell
Sep 23, 2000·Blood Cells, Molecules & Diseases·G PapanikolaouD Loukopoulos
Oct 6, 2000·Journal of Hepatology·P AdamsL W Powell
Mar 7, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A L FracanzaniS Fargion
May 9, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A S TavillUNKNOWN American Gastroenterological Association
Apr 16, 2003·Annals of Internal Medicine·Elizabeth D MorrisonKris V Kowdley
Apr 6, 2004·Clinical Chemistry and Laboratory Medicine : CCLM·Francesco De MarcoVincenzo De Simone
Apr 9, 2004·Blood·Rolf Vaern AndersenBørge Grønne Nordestgaard
Jun 4, 2004·The New England Journal of Medicine·Antonello Pietrangelo
Oct 7, 2004·Journal of Medical Genetics·K J H RobsonJ Rochette
Mar 5, 2005·Annals of Hematology·Massimo Franchini, Dino Veneri
Jun 29, 2005·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·J A Solís-Herruzo, P Solís Muñoz
Nov 30, 2005·Seminars in Liver Disease·Antonello Pietrangelo
Dec 14, 2005·Gastroenterology·Elizabeth E PowellJulie R Jonsson
Apr 22, 2006·Clinical Chemistry·Dorine W SwinkelsJoannes J M Marx
Jun 21, 2006·Comprehensive Therapy·Cathrine J Wheeler, Kris V Kowdley
Aug 2, 2006·Annals of Internal Medicine·Evelyn P WhitlockPaula R Smith
Jan 2, 2008·Gastroenterology·Debbie TrinderJohn K Olynyk
Jan 18, 2008·The New England Journal of Medicine·Katrina J AllenDorota M Gertig
Jan 18, 2008·The New England Journal of Medicine·Bruce R Bacon, Robert S Britton
Feb 19, 2008·Journal of Clinical Gastroenterology·Paolo FabrisAnnarosa Floreani
Feb 29, 2008·Journal of Hepatology·Josep M Llovet, Jordi Bruix
Apr 22, 2008·Critical Care Nursing Clinics of North America·Christopher Fowler
May 24, 2008·The New England Journal of Medicine·Jill Waalen, Ernest Beutler
Jun 21, 2008·Diabetes Research and Clinical Practice·E P O'SullivanC H Walsh
Aug 21, 2008·Critical Reviews in Clinical Laboratory Sciences·Oyekoya T AyonrindeJohn K Olynyk
Aug 30, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·John K OlynykBruce R Bacon

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Citations

Jun 8, 2011·Digestive Diseases and Sciences·Albert J Czaja
Mar 28, 2013·Expert Opinion on Medical Diagnostics·Alberto Piperno
Aug 27, 2010·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Silvia FargionAnna Ludovica Fracanzani
Mar 10, 2016·Journal of Endocrinological Investigation·C PelusiR Pasquali
Mar 17, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Marnie J WoodGrant A Ramm
Jun 19, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Edouard Bardou-JacquetPierre Brissot
Dec 17, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·Ludivine LegrosDominique Guyader
Jan 22, 2013·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Luca ValentiStefano Romeo
Feb 13, 2016·Journal of Gastroenterology and Hepatology·Sara PelucchiAlberto Piperno
Mar 16, 2016·Lancet·Lawrie W PowellYves Deugnier
Oct 4, 2014·World Journal of Gastroenterology : WJG·Paola DongiovanniLuca Valenti
Nov 15, 2019·American Journal of Hematology·Raffaela RamettaLuca Valenti
Mar 24, 2016·World Journal of Hepatology·Menaka Sivakumar, Lawrie W Powell
Aug 23, 2019·American Journal of Clinical Oncology·Mark J W McPhailAbid Suddle
Jan 31, 2021·International Journal of Molecular Sciences·Sara PelucchiAlberto Piperno

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