Hemocompatibility assessment of carbonic anhydrase modified hollow fiber membranes for artificial lungs.

Artificial Organs
Heung-Il OhWilliam R Wagner

Abstract

Hollow fiber membrane (HFM)-based artificial lungs can require a large blood-contacting membrane surface area to provide adequate gas exchange. However, such a large surface area presents significant challenges to hemocompatibility. One method to improve carbon dioxide (CO(2)) transfer efficiency might be to immobilize carbonic anhydrase (CA) onto the surface of conventional HFMs. By catalyzing the dehydration of bicarbonate in blood, CA has been shown to facilitate diffusion of CO(2) toward the fiber membranes. This study evaluated the impact of surface modifying a commercially available microporous HFM-based artificial lung on fiber blood biocompatibility. A commercial poly(propylene) Celgard HFM surface was coated with a siloxane, grafted with amine groups, and then attached with CA which has been shown to facilitate diffusion of CO(2) toward the fiber membranes. Results following acute ovine blood contact indicated no significant reduction in platelet deposition or activation with the siloxane coating or the siloxane coating with grafted amines relative to base HFMs. However, HFMs with attached CA showed a significant reduction in both platelet deposition and activation compared with all other fiber types. These findings, a...Continue Reading

References

Feb 1, 1995·Biomaterials·Y TamadaY Ikada
Nov 25, 1998·Journal of Biomedical Materials Research·J G CalderonR B Timmons
Oct 23, 2004·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Heide J EashWilliam J Federspiel
Apr 17, 2007·Biomaterials·Joel L KaarWilliam J Federspiel
Nov 17, 2007·Artificial Organs·Carl A JohnsonWilliam R Wagner

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Citations

Mar 16, 2011·Artificial Organs·Paul S Malchesky
Jul 30, 2014·Biotechnology Letters·Nelly WungMarianne J Ellis
Sep 11, 2012·Journal of Membrane Science·David T ArazawaWilliam J Federspiel
Feb 12, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Sang-Ho YeWilliam R Wagner
May 20, 2016·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Hany Hazfiza Manap, Ahmad Khairi Abdul Wahab
Aug 30, 2011·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·S VandenbergheJ F Antaki
Nov 15, 2017·Current Opinion in Critical Care·Francesco AlessandriMarco V Ranieri
Oct 25, 2020·Artificial Organs·Justyna SwolRoberto Lorusso
Oct 2, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Yuya SoneShoichiro Asayama

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