Hemodialysis and L-arginine, but not D-arginine, correct renal failure-associated endothelial dysfunction

Kidney International
M F HandD J Webb

Abstract

In end-stage renal failure (ESRF) symptomatic hemodialysis-related hypotension may prevent effective provision of renal replacement therapy. Endogenous inhibitors of nitric oxide synthase accumulate in ESRF and are cleared by dialysis. We, therefore, hypothesised that removal of these inhibitors by hemodialysis would increase endothelial nitric oxide generation and promote venodilation. In vivo responses of norepinephrine preconstricted dorsal hand veins to locally active doses of acetylcholine (an activator of nitric oxide synthase) and glyceryl trinitrate (GTN; a nitric oxide donor) were examined in patients undergoing maintenance hemodialysis for ESRF and in healthy age- and sex-matched controls. Patient studies were undertaken before and after dialysis. Studies before dialysis were repeated with co-infusion of either L-arginine or its inactive enantiomer D-arginine. Venodilation in response to acetylcholine was impaired before, and corrected by, dialysis whereas venodilation to GTN was similar before and after dialysis. Venodilation in response to acetylcholine before dialysis was restored by co-infusion of L- but not D-arginine. Therefore, patients with ESRF undergoing hemodialysis have impaired acetylcholine-mediated veno...Continue Reading

References

Apr 1, 1979·Kidney International·B WehleJ Bergström
Jan 1, 1975·Annual Review of Biochemistry·G L Cantoni
Jan 1, 1992·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·J P KoomanK M Leunissen
May 1, 1992·Journal of Vascular Research·S Schwarzacher, G Raberger
Feb 1, 1991·Kidney International·J T Daugirdas
Jan 16, 1989·Biochemical and Biophysical Research Communications·R M Palmer, S Moncada
Feb 1, 1989·Journal of Hypertension·C E EvansS A Hewson
Jan 1, 1988·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·J R BradleyA J Cowley
Jun 11, 1988·British Medical Journal·J R BradleyA J Cowley
Nov 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·I SakumaR Levi
Jun 30, 1988·Biochemical and Biophysical Research Communications·R M PalmerS Moncada
May 1, 1972·Journal of Applied Physiology·W Van Beaumont
Oct 1, 1969·The Journal of Clinical Investigation·R Zelis, D T Mason
Mar 1, 1981·British Journal of Clinical Pharmacology·W H Aellig
May 1, 1981·Hypertension·M ChaignonE L Bravo
Dec 1, 1993·Journal of Hypertension·W G HaynesD J Webb
May 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·A J CayatteR A Cohen
Mar 1, 1994·Kidney International·R J MacAllisterP Vallance
May 1, 1994·Journal of Applied Physiology·N M DietzM J Joyner
Jun 1, 1995·British Journal of Pharmacology·R Sorrentino, A Pinto
Jul 15, 1995·Lancet·P VallanceT Malinski
Jul 1, 1995·Annals of Internal Medicine·K YokokawaA K Mandel
Jan 1, 1995·Journal of Vascular Research·D J Webb
Sep 1, 1994·Kidney International·T A IkizlerR M Hakim

❮ Previous
Next ❯

Citations

Jan 17, 2012·International Urology and Nephrology·Hasan Ali GümrükçüoğluMustafa Tuncer
Apr 5, 2001·Current Atherosclerosis Reports·J P Cooke, R K Oka
Dec 11, 2003·Atherosclerosis. Supplements·Rainer H Böger, Carmine Zoccali
Dec 11, 2003·Atherosclerosis. Supplements·Karsten Sydow, Thomas Münzel
Aug 26, 2006·Nature Clinical Practice. Nephrology·Chris Baylis
Sep 6, 2000·Kidney International·M Ketteler, E Ritz
Mar 13, 2003·Kidney International·David O McGregorM Gary Nicholls
Jun 22, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·P StenvinkelJ Bergström
Jun 17, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Markus KoschMartin Hausberg
Feb 10, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Adrian CovicMaria Covic
Nov 21, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Hoon Young ChoiDae-Suk Han
Mar 23, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Aysun Aybal KutlugünMustafa Arici
Nov 1, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Nicolas AmabileGérard M London
Nov 18, 1998·Current Opinion in Nephrology and Hypertension·S Klahr
Apr 13, 2006·Current Opinion in Nephrology and Hypertension·Carmine Zoccali, Jan T Kielstein
Aug 10, 2006·Clinical and Experimental Pharmacology & Physiology·T M C BruniniA C Mendes Ribeiro
Jun 21, 2011·Seminars in Dialysis·Noémie Jourde-ChichePhilippe Brunet
Apr 12, 2011·American Journal of Physiology. Renal Physiology·Roy L SutliffW Charles O'Neill
Apr 27, 2012·Cardiology Research and Practice·Gareth WilliamsJanice C S Tsui
Oct 18, 2008·Renal Failure·Monika TomićIvica Markota
Feb 13, 2001·Kidney International. Supplement·J T KielsteinR H Böger
Feb 19, 2002·Kidney International·Dominic S C RajRichard A Robbins
Sep 5, 2001·Kidney International·S T MorrisA G Jardine
Apr 16, 2003·Kidney International. Supplement·Danilo FliserStefanie M Bode-Böger
Aug 3, 2006·Kidney International·B S Dixon
Oct 19, 2006·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Patrícia F ReisAntônio C Mendes-Ribeiro
Apr 25, 2007·Néphrologie & thérapeutique·Jan T Kielstein, Danilo Fliser
Aug 23, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Jan T Kielstein, Carmine Zoccali
Jul 15, 2004·Seminars in Dialysis·Michael Flanigan
May 18, 2004·Seminars in Dialysis·Shubho R SarkarNathan W Levin
Mar 10, 2005·The Medical Clinics of North America·Martin J Andersen, Rajiv Agarwal
Jun 5, 2015·Frontiers in Physiology·Omar Z AmeerJacqueline K Phillips
Oct 24, 2014·Journal of Human Hypertension·O A Gutiérrez-AdrianzénC R M Rodrigues Sobrinho
Mar 21, 2012·The Journal of International Medical Research·M Yusuf AlsagaffY Tomino
Jul 16, 2008·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·A M V SilvaM C Irigoyen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antianginal Drugs: Mechanisms of Action

Antianginal drugs, including nitrates, beta-blockers, and calcium channel blockers, are used in the treatment of angina pectoris. Here is the latest research on their use and their mechanism of action.

Related Papers

Seminars in Dialysis
Andrew E LazarMahboob Rahman
Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
K Amann, E Ritz
© 2022 Meta ULC. All rights reserved